Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.

Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.

The advent of anti-TNF biological agents has been a massive advance in our treatment of RA and other inflammatory diseases. However, it is acknowledged that there are major drawbacks, the greatest being cost. There is, therefore, clearly a massive market for small molecular weight inhibitors that wo...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ:	Foxwell, B, Andreakos, E, Brennan, F, Feldmann, M, Smith, C, Conron, M
Ձևաչափ:	Journal article
Լեզու:	English
Հրապարակվել է:	2003

Նմանատիպ նյութեր

Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.
‌: Sumariwalla, P, և այլն
Հրապարակվել է: (2009)

Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
‌: Andreakos, E, և այլն
Հրապարակվել է: (2002)

Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumour necrosis factor production.
‌: Foxwell, B, և այլն
Հրապարակվել է: (2000)

Expression of an efficient small molecular weight tumour necrosis factor/lymphotoxin antagonist.
‌: Neve, R, և այլն
Հրապարակվել է: (1996)

Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.
‌: Brennan, F, և այլն
Հրապարակվել է: (1995)

Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
‌: Andreakos, E, և այլն
Հրապարակվել է: (2004)

Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.
‌: Sacre, S, և այլն
Հրապարակվել է: (2007)

IκB kinase 2 but not NF-κB-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction
‌: Andreakos, E, և այլն
Հրապարակվել է: (2003)

Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
‌: Andreakos, E, և այլն
Հրապարակվել է: (2003)

NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts
‌: Smith, C, և այլն
Հրապարակվել է: (2001)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
‌: Smith, C, և այլն
Հրապարակվել է: (2001)

What is the mechanism of action of anti-tumour necrosis factor-alpha antibody in rheumatoid arthritis?
‌: Feldmann, M
Հրապարակվել է: (1996)

Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
‌: Maini, R, և այլն
Հրապարակվել է: (1995)

Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
‌: Cope, A, և այլն
Հրապարակվել է: (1993)

Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.
‌: Maini, R, և այլն
Հրապարակվել է: (1999)

The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
‌: Andreakos, E, և այլն
Հրապարակվել է: (2005)

Endotoxin signaling in human macrophages: signaling via an alternate mechanism.
‌: Sacre, S, և այլն
Հրապարակվել է: (2004)

Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins.
‌: Scallon, B, և այլն
Հրապարակվել է: (1995)

High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.
‌: Horwood, N, և այլն
Հրապարակվել է: (2002)

TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
‌: Ciesielski, C, և այլն
Հրապարակվել է: (2002)

Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.
‌: Wales, J, և այլն
Հրապարակվել է: (2007)

Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination
‌: Wales, J, և այլն
Հրապարակվել է: (2007)

TNFα-induced macrophage chemokine secretion is more dependent on NF-κB expression than lipopolysaccharides-induced macrophage chemokine secretion
‌: Ciesielski, C, և այլն
Հրապարակվել է: (2002)

The severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics are not influenced by the tumour necrosis factor receptor polymorphism incriminated in multiple sclerosis
‌: Watts, L, և այլն
Հրապարակվել է: (2018)

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed
‌: Feldmann, M, և այլն
Հրապարակվել է: (2020)

Comparison of patterns of expression of tumour necrosis factor, lymphotoxin and interleukin-6 mRNA.
‌: Turner, M, և այլն
Հրապարակվել է: (1988)

Molecular therapeutic targets in rheumatoid arthritis.
‌: Sacre, S, և այլն
Հրապարակվել է: (2005)

The structure of tumour necrosis factor--implications for biological function.
‌: Jones, E, և այլն
Հրապարակվել է: (1990)

Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha.
‌: Williams, R, և այլն
Հրապարակվել է: (2000)

Use of anti-tumor necrosis factor antibodies in rheumatoid arthritis.
‌: Feldmann, M, և այլն
Հրապարակվել է: (1994)

Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
‌: Andreakos, E, և այլն
Հրապարակվել է: (2006)

Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.
‌: Taylor, P, և այլն
Հրապարակվել է: (2004)

Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
‌: Brennan, F, և այլն
Հրապարակվել է: (1997)

Updated consensus statement on tumour necrosis factor blocking agents for the treatment of rheumatoid arthritis (May 2000).
‌: Furst, D, և այլն
Հրապարակվել է: (2000)

Tumour necrosis factor.
‌: Van Der Merwe, P
Հրապարակվել է: (1988)

Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
‌: Brennan, F, և այլն
Հրապարակվել է: (2002)

Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
‌: Andreakos, E, և այլն
Հրապարակվել է: (2003)

Tumor necrosis factor-alpha (TNF) triggers a cytokine cascade yielding postoperative cognitive decline
‌: Terrando, N, և այլն
Հրապարակվել է: (2010)

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
‌: Kiriakidis, S, և այլն
Հրապարակվել է: (2003)

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
‌: Kiriakidis, S, և այլն
Հրապարակվել է: (2003)