MAIT cell activation augments adenovirus vector vaccine immunogenicity

MAIT cell activation augments adenovirus vector vaccine immunogenicity

Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment early immune responses and contribute to protection. We hypothesized that MAIT cells may have inherent adjuvant activity in vaccine platforms that use replication-incompetent adenovirus vectors. In mice and hum...

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Bibliographic Details
Main Authors: Provine, N, Amini, A, Garner, L, Spencer, A, Dold, C, Hutchings, C, Silva Reyes, L, Fitzpatrick, M, Chinnakannan, S, Oguti, B, Raymond, M, Ulaszewska, M, Troise, F, Sharpe, H, Morgan, S, Hinks, T, Lambe, T, Capone, S, Folgori, A, Barnes, E, Rollier, C, Pollard, A, Klenerman, P
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2021

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