A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map.
Karyotypic analysis in a patient with Peutz-Jeghers' syndrome demonstrated a pericentric inversion on chromosome 6. Further investigation was undertaken using fluorescence in situ hybridisation (FISH) with yeast artificial chromosome clones selected to contain genetic markers from chromosome 6,...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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1996
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| _version_ | 1797104232281669632 |
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| author | Markie, D Huson, S Maher, E Davies, A Tomlinson, I Bodmer, W |
| author_facet | Markie, D Huson, S Maher, E Davies, A Tomlinson, I Bodmer, W |
| author_sort | Markie, D |
| collection | OXFORD |
| description | Karyotypic analysis in a patient with Peutz-Jeghers' syndrome demonstrated a pericentric inversion on chromosome 6. Further investigation was undertaken using fluorescence in situ hybridisation (FISH) with yeast artificial chromosome clones selected to contain genetic markers from chromosome 6, and a probe for the centromeric alphoid repeat array. This analysis located one inversion breakpoint within the alphoid array, in a 1-cM interval between D6S257 and D6S402, and the other in a 4-cM interval between D6S403 and D6S311. The oestrogen receptor gene locus (ESR) is excluded from the latter interval. |
| first_indexed | 2024-03-07T06:30:59Z |
| format | Journal article |
| id | oxford-uuid:f5fbb185-0da4-49bb-a9e8-4abfa9015d6c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:30:59Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:f5fbb185-0da4-49bb-a9e8-4abfa9015d6c2022-03-27T12:31:30ZA pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f5fbb185-0da4-49bb-a9e8-4abfa9015d6cEnglishSymplectic Elements at Oxford1996Markie, DHuson, SMaher, EDavies, ATomlinson, IBodmer, WKaryotypic analysis in a patient with Peutz-Jeghers' syndrome demonstrated a pericentric inversion on chromosome 6. Further investigation was undertaken using fluorescence in situ hybridisation (FISH) with yeast artificial chromosome clones selected to contain genetic markers from chromosome 6, and a probe for the centromeric alphoid repeat array. This analysis located one inversion breakpoint within the alphoid array, in a 1-cM interval between D6S257 and D6S402, and the other in a 4-cM interval between D6S403 and D6S311. The oestrogen receptor gene locus (ESR) is excluded from the latter interval. |
| spellingShingle | Markie, D Huson, S Maher, E Davies, A Tomlinson, I Bodmer, W A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map. |
| title | A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map. |
| title_full | A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map. |
| title_fullStr | A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map. |
| title_full_unstemmed | A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map. |
| title_short | A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map. |
| title_sort | pericentric inversion of chromosome six in a patient with peutz jeghers syndrome and the use of fish to localise the breakpoints on a genetic map |
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