Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cer...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer
2023
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| _version_ | 1811140294497796096 |
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| author | Ilg, W Milne, S Schmitz-Hübsch, T Alcock, L Beichert, L Bertini, E Mohamed Ibrahim, N Dawes, H Gomez, CM Hanagasi, H Kinnunen, KM Minnerop, M Németh, AH Newman, J Ng, YS Rentz, C Samanci, B Shah, VV Summa, S Vasco, G McNames, J Horak, FB |
| author_facet | Ilg, W Milne, S Schmitz-Hübsch, T Alcock, L Beichert, L Bertini, E Mohamed Ibrahim, N Dawes, H Gomez, CM Hanagasi, H Kinnunen, KM Minnerop, M Németh, AH Newman, J Ng, YS Rentz, C Samanci, B Shah, VV Summa, S Vasco, G McNames, J Horak, FB |
| author_sort | Ilg, W |
| collection | OXFORD |
| description | With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials. This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes. |
| first_indexed | 2024-09-25T04:19:42Z |
| format | Journal article |
| id | oxford-uuid:f6103cc9-ae58-4c96-b6f1-244c2cce352a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:19:42Z |
| publishDate | 2023 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:f6103cc9-ae58-4c96-b6f1-244c2cce352a2024-07-24T19:39:42ZQuantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor BiomarkersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f6103cc9-ae58-4c96-b6f1-244c2cce352aEnglishJisc Publications RouterSpringer2023Ilg, WMilne, SSchmitz-Hübsch, TAlcock, LBeichert, LBertini, EMohamed Ibrahim, NDawes, HGomez, CMHanagasi, HKinnunen, KMMinnerop, MNémeth, AHNewman, JNg, YSRentz, CSamanci, BShah, VVSumma, SVasco, GMcNames, JHorak, FBWith disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials. This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes. |
| spellingShingle | Ilg, W Milne, S Schmitz-Hübsch, T Alcock, L Beichert, L Bertini, E Mohamed Ibrahim, N Dawes, H Gomez, CM Hanagasi, H Kinnunen, KM Minnerop, M Németh, AH Newman, J Ng, YS Rentz, C Samanci, B Shah, VV Summa, S Vasco, G McNames, J Horak, FB Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers |
| title | Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers |
| title_full | Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers |
| title_fullStr | Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers |
| title_full_unstemmed | Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers |
| title_short | Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers |
| title_sort | quantitative gait and balance outcomes for ataxia trials consensus recommendations by the ataxia global initiative working group on digital motor biomarkers |
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