The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans.
The lower rates of some cancers in Asian countries than in Western countries may be partly because of diet, although the mechanisms are unknown. The aim of this cross-sectional study was to determine whether a plant-based (vegan) diet is associated with a lower circulating level of insulin-like grow...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2002
|
| _version_ | 1797104262323372032 |
|---|---|
| author | Allen, N Appleby, P Davey, G Kaaks, R Rinaldi, S Key, T |
| author_facet | Allen, N Appleby, P Davey, G Kaaks, R Rinaldi, S Key, T |
| author_sort | Allen, N |
| collection | OXFORD |
| description | The lower rates of some cancers in Asian countries than in Western countries may be partly because of diet, although the mechanisms are unknown. The aim of this cross-sectional study was to determine whether a plant-based (vegan) diet is associated with a lower circulating level of insulin-like growth factor I (IGF-I) compared with a meat-eating or lacto-ovo-vegetarian diet among 292 British women, ages 20-70 years. The mean serum IGF-I concentration was 13% lower in 92 vegan women compared with 99 meat-eaters and 101 vegetarians (P = 0.0006). The mean concentrations of both serum IGF-binding protein (IGFBP)-1 and IGFBP-2 were 20-40% higher in vegan women compared with meat-eaters and vegetarians (P = 0.005 and P = 0.0008 for IGFBP-1 and IGFBP-2, respectively). There were no significant differences in IGFBP-3, C-peptide, or sex hormone-binding globulin concentrations between the diet groups. Intake of protein rich in essential amino acids was positively associated with serum IGF-I (Pearson partial correlation coefficient; r = 0.27; P < 0.0001) and explained most of the differences in IGF-I concentration between the diet groups. These data suggest that a plant-based diet is associated with lower circulating levels of total IGF-I and higher levels of IGFBP-1 and IGFBP-2. |
| first_indexed | 2024-03-07T06:31:26Z |
| format | Journal article |
| id | oxford-uuid:f61f06f2-ce5c-4d40-892c-7429f54d1518 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:31:26Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:f61f06f2-ce5c-4d40-892c-7429f54d15182022-03-27T12:32:40ZThe associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f61f06f2-ce5c-4d40-892c-7429f54d1518EnglishSymplectic Elements at Oxford2002Allen, NAppleby, PDavey, GKaaks, RRinaldi, SKey, TThe lower rates of some cancers in Asian countries than in Western countries may be partly because of diet, although the mechanisms are unknown. The aim of this cross-sectional study was to determine whether a plant-based (vegan) diet is associated with a lower circulating level of insulin-like growth factor I (IGF-I) compared with a meat-eating or lacto-ovo-vegetarian diet among 292 British women, ages 20-70 years. The mean serum IGF-I concentration was 13% lower in 92 vegan women compared with 99 meat-eaters and 101 vegetarians (P = 0.0006). The mean concentrations of both serum IGF-binding protein (IGFBP)-1 and IGFBP-2 were 20-40% higher in vegan women compared with meat-eaters and vegetarians (P = 0.005 and P = 0.0008 for IGFBP-1 and IGFBP-2, respectively). There were no significant differences in IGFBP-3, C-peptide, or sex hormone-binding globulin concentrations between the diet groups. Intake of protein rich in essential amino acids was positively associated with serum IGF-I (Pearson partial correlation coefficient; r = 0.27; P < 0.0001) and explained most of the differences in IGF-I concentration between the diet groups. These data suggest that a plant-based diet is associated with lower circulating levels of total IGF-I and higher levels of IGFBP-1 and IGFBP-2. |
| spellingShingle | Allen, N Appleby, P Davey, G Kaaks, R Rinaldi, S Key, T The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. |
| title | The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. |
| title_full | The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. |
| title_fullStr | The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. |
| title_full_unstemmed | The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. |
| title_short | The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. |
| title_sort | associations of diet with serum insulin like growth factor i and its main binding proteins in 292 women meat eaters vegetarians and vegans |
| work_keys_str_mv | AT allenn theassociationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT applebyp theassociationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT daveyg theassociationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT kaaksr theassociationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT rinaldis theassociationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT keyt theassociationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT allenn associationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT applebyp associationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT daveyg associationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT kaaksr associationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT rinaldis associationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans AT keyt associationsofdietwithseruminsulinlikegrowthfactorianditsmainbindingproteinsin292womenmeateatersvegetariansandvegans |