The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted prog...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797104281024724992 |
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| author | Luc, S Luis, T Boukarabila, H Macaulay, I Buza-Vidas, N Bouriez-Jones, T Lutteropp, M Woll, P Loughran, S Mead, A Hultquist, A Brown, J Mizukami, T Matsuoka, S Ferry, H Anderson, K Duarte, S Atkinson, D Soneji, S Domanski, A Farley, A Sanjuan-Pla, A Carella, C Patient, R de Bruijn, M |
| author_facet | Luc, S Luis, T Boukarabila, H Macaulay, I Buza-Vidas, N Bouriez-Jones, T Lutteropp, M Woll, P Loughran, S Mead, A Hultquist, A Brown, J Mizukami, T Matsuoka, S Ferry, H Anderson, K Duarte, S Atkinson, D Soneji, S Domanski, A Farley, A Sanjuan-Pla, A Carella, C Patient, R de Bruijn, M |
| author_sort | Luc, S |
| collection | OXFORD |
| description | The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus. |
| first_indexed | 2024-03-07T06:31:38Z |
| format | Journal article |
| id | oxford-uuid:f62d3ce1-1e10-4c07-9fdd-184570c70f65 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:31:38Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:f62d3ce1-1e10-4c07-9fdd-184570c70f652022-03-27T12:33:16ZThe earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f62d3ce1-1e10-4c07-9fdd-184570c70f65EnglishSymplectic Elements at Oxford2012Luc, SLuis, TBoukarabila, HMacaulay, IBuza-Vidas, NBouriez-Jones, TLutteropp, MWoll, PLoughran, SMead, AHultquist, ABrown, JMizukami, TMatsuoka, SFerry, HAnderson, KDuarte, SAtkinson, DSoneji, SDomanski, AFarley, ASanjuan-Pla, ACarella, CPatient, Rde Bruijn, MThe stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus. |
| spellingShingle | Luc, S Luis, T Boukarabila, H Macaulay, I Buza-Vidas, N Bouriez-Jones, T Lutteropp, M Woll, P Loughran, S Mead, A Hultquist, A Brown, J Mizukami, T Matsuoka, S Ferry, H Anderson, K Duarte, S Atkinson, D Soneji, S Domanski, A Farley, A Sanjuan-Pla, A Carella, C Patient, R de Bruijn, M The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. |
| title | The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. |
| title_full | The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. |
| title_fullStr | The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. |
| title_full_unstemmed | The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. |
| title_short | The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. |
| title_sort | earliest thymic t cell progenitors sustain b cell and myeloid lineage potential |
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