Risk of Parkinson's disease dementia related to level I MDS PD-MCI
<p><strong>Background:</strong> The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Mo...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
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Wiley
2019
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| _version_ | 1797104292919771136 |
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| author | Hoogland, J Boel, JA De Bie, RMA Schmand, BA Geskus, RB Dalrymple-Alford, JC Marras, C Adler, CH Weintraub, D Junque, C Pedersen, KF Mollenhauer, B Goldman, JG Tröster, AI Burn, DJ Litvan, I Geurtsen, GJ |
| author_facet | Hoogland, J Boel, JA De Bie, RMA Schmand, BA Geskus, RB Dalrymple-Alford, JC Marras, C Adler, CH Weintraub, D Junque, C Pedersen, KF Mollenhauer, B Goldman, JG Tröster, AI Burn, DJ Litvan, I Geurtsen, GJ |
| author_sort | Hoogland, J |
| collection | OXFORD |
| description | <p><strong>Background:</strong> The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.</p> <p><strong>Methods:</strong> We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson’s disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson’s disease dementia.</p> <p><strong>Results:</strong> Level I mild cognitive impairment in PD,increasing age, male sex, and severity of PD motorsigns independently increased the hazard of Parkinson’s disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson’s disease dementia.</p> <p><strong>Conclusions:</strong> Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson’s disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria.</p> |
| first_indexed | 2024-03-07T06:31:49Z |
| format | Journal article |
| id | oxford-uuid:f63b662e-f65a-47ab-809a-bb087a8d8ab3 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:31:49Z |
| publishDate | 2019 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:f63b662e-f65a-47ab-809a-bb087a8d8ab32022-03-27T12:33:39ZRisk of Parkinson's disease dementia related to level I MDS PD-MCIJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f63b662e-f65a-47ab-809a-bb087a8d8ab3Symplectic Elements at OxfordWiley2019Hoogland, JBoel, JADe Bie, RMASchmand, BAGeskus, RBDalrymple-Alford, JCMarras, CAdler, CHWeintraub, DJunque, CPedersen, KFMollenhauer, BGoldman, JGTröster, AIBurn, DJLitvan, IGeurtsen, GJ<p><strong>Background:</strong> The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.</p> <p><strong>Methods:</strong> We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson’s disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson’s disease dementia.</p> <p><strong>Results:</strong> Level I mild cognitive impairment in PD,increasing age, male sex, and severity of PD motorsigns independently increased the hazard of Parkinson’s disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson’s disease dementia.</p> <p><strong>Conclusions:</strong> Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson’s disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria.</p> |
| spellingShingle | Hoogland, J Boel, JA De Bie, RMA Schmand, BA Geskus, RB Dalrymple-Alford, JC Marras, C Adler, CH Weintraub, D Junque, C Pedersen, KF Mollenhauer, B Goldman, JG Tröster, AI Burn, DJ Litvan, I Geurtsen, GJ Risk of Parkinson's disease dementia related to level I MDS PD-MCI |
| title | Risk of Parkinson's disease dementia related to level I MDS PD-MCI |
| title_full | Risk of Parkinson's disease dementia related to level I MDS PD-MCI |
| title_fullStr | Risk of Parkinson's disease dementia related to level I MDS PD-MCI |
| title_full_unstemmed | Risk of Parkinson's disease dementia related to level I MDS PD-MCI |
| title_short | Risk of Parkinson's disease dementia related to level I MDS PD-MCI |
| title_sort | risk of parkinson s disease dementia related to level i mds pd mci |
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