A reference panel of 64,976 haplotypes for genotype imputation

We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in th...

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Podrobná bibliografie
Hlavní autoři: Kretzschmar, W, Mahajan, A, Sharp, K, McCarthy, M, Haplotype Reference Consortium
Médium: Journal article
Jazyk:English
Vydáno: Nature Publishing Group 2016