Chronic pedunculopontine nucleus stimulation restores functional connectivity.
The mechanisms of deep brain stimulation (DBS) are poorly understood. Earlier, high-frequency DBS has been thought to represent a depolarization block of the target area and low-frequency stimulation has been thought to 'drive' neuronal activity. We investigated the long-term effect of low...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797104318656020480 |
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| author | Schweder, P Joint, C Hansen, P Green, A Quaghebeur, G Aziz, T |
| author_facet | Schweder, P Joint, C Hansen, P Green, A Quaghebeur, G Aziz, T |
| author_sort | Schweder, P |
| collection | OXFORD |
| description | The mechanisms of deep brain stimulation (DBS) are poorly understood. Earlier, high-frequency DBS has been thought to represent a depolarization block of the target area and low-frequency stimulation has been thought to 'drive' neuronal activity. We investigated the long-term effect of low-frequency DBS in a longitudinal imaging study of a patient who received bilateral pedunculopontine nucleus stimulation. We used the diffusion tensor imaging techniques including probabilistic tractography and topographic mapping to analyze long-term changes in connectivity with low-frequency DBS. Post-DBS connectivity analysis suggested a normalization of pathological pedunculopontine nucleus connectivity with DBS therapy. These findings may help elucidate the mechanisms of DBS, suggesting neuroplasticity involving a reorganization of target connectivity long term. This is the first reported case showing neuroimaging evidence of neuroplasticity after low-frequency DBS. |
| first_indexed | 2024-03-07T06:32:06Z |
| format | Journal article |
| id | oxford-uuid:f654abb7-7697-4d9f-be08-66b65133d59b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:32:06Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:f654abb7-7697-4d9f-be08-66b65133d59b2022-03-27T12:34:26ZChronic pedunculopontine nucleus stimulation restores functional connectivity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f654abb7-7697-4d9f-be08-66b65133d59bEnglishSymplectic Elements at Oxford2010Schweder, PJoint, CHansen, PGreen, AQuaghebeur, GAziz, TThe mechanisms of deep brain stimulation (DBS) are poorly understood. Earlier, high-frequency DBS has been thought to represent a depolarization block of the target area and low-frequency stimulation has been thought to 'drive' neuronal activity. We investigated the long-term effect of low-frequency DBS in a longitudinal imaging study of a patient who received bilateral pedunculopontine nucleus stimulation. We used the diffusion tensor imaging techniques including probabilistic tractography and topographic mapping to analyze long-term changes in connectivity with low-frequency DBS. Post-DBS connectivity analysis suggested a normalization of pathological pedunculopontine nucleus connectivity with DBS therapy. These findings may help elucidate the mechanisms of DBS, suggesting neuroplasticity involving a reorganization of target connectivity long term. This is the first reported case showing neuroimaging evidence of neuroplasticity after low-frequency DBS. |
| spellingShingle | Schweder, P Joint, C Hansen, P Green, A Quaghebeur, G Aziz, T Chronic pedunculopontine nucleus stimulation restores functional connectivity. |
| title | Chronic pedunculopontine nucleus stimulation restores functional connectivity. |
| title_full | Chronic pedunculopontine nucleus stimulation restores functional connectivity. |
| title_fullStr | Chronic pedunculopontine nucleus stimulation restores functional connectivity. |
| title_full_unstemmed | Chronic pedunculopontine nucleus stimulation restores functional connectivity. |
| title_short | Chronic pedunculopontine nucleus stimulation restores functional connectivity. |
| title_sort | chronic pedunculopontine nucleus stimulation restores functional connectivity |
| work_keys_str_mv | AT schwederp chronicpedunculopontinenucleusstimulationrestoresfunctionalconnectivity AT jointc chronicpedunculopontinenucleusstimulationrestoresfunctionalconnectivity AT hansenp chronicpedunculopontinenucleusstimulationrestoresfunctionalconnectivity AT greena chronicpedunculopontinenucleusstimulationrestoresfunctionalconnectivity AT quaghebeurg chronicpedunculopontinenucleusstimulationrestoresfunctionalconnectivity AT azizt chronicpedunculopontinenucleusstimulationrestoresfunctionalconnectivity |