REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomers leads to neurodegeneration. Bioche...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Ryan, BJ, Bengoa-Vergniory, N, Williamson, M, Kirkiz, E, Roberts, R, Corda, G, Sloan, M, Saqlain, S, Cherubini, M, Poppinga, J, Bogtofte, H, Cioroch, M, Hester, S, Wade-Martins, R
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	Society for Neuroscience 2021

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