REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomers leads to neurodegeneration. Bioche...

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Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Ryan, BJ, Bengoa-Vergniory, N, Williamson, M, Kirkiz, E, Roberts, R, Corda, G, Sloan, M, Saqlain, S, Cherubini, M, Poppinga, J, Bogtofte, H, Cioroch, M, Hester, S, Wade-Martins, R
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Society for Neuroscience 2021

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