REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model

Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomers leads to neurodegeneration. Bioche...

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Bibliografische gegevens
Hoofdauteurs:	Ryan, BJ, Bengoa-Vergniory, N, Williamson, M, Kirkiz, E, Roberts, R, Corda, G, Sloan, M, Saqlain, S, Cherubini, M, Poppinga, J, Bogtofte, H, Cioroch, M, Hester, S, Wade-Martins, R
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Society for Neuroscience 2021

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