REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model
Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomers leads to neurodegeneration. Bioche...
| Main Authors: | , , , , , , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
Society for Neuroscience
2021
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