Development of bifunctional organic superbases for catalytic enantioselective synthesis
<p><strong>Chapter I</strong> describes the concept of chirality and enantioselective synthesis. Organocatalysis is then introduced, with a focus on bifunctional organocatalysis and superbases in asymmetric methodology. Finally, bifunctional iminophosphorane catalysis is introduced...
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| Formatua: | Thesis |
| Hizkuntza: | English |
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2024
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| _version_ | 1826313641667854336 |
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| author | Rozsar, D |
| author2 | Dixon, D |
| author_facet | Dixon, D Rozsar, D |
| author_sort | Rozsar, D |
| collection | OXFORD |
| description | <p><strong>Chapter I</strong> describes the concept of chirality and enantioselective synthesis. Organocatalysis is then introduced, with a focus on bifunctional organocatalysis and superbases in asymmetric methodology. Finally, bifunctional iminophosphorane catalysis is introduced and discussed.</p>
<p><strong>Chapter II</strong> describes the development of the first organocatalytic conjugate addition to unactivated α,β-unsaturated amides, exemplified by a highly enantioselective sulfa-Michael addition, and along with that the development of 3rd generation BIMP catalysts.</p>
<p><strong>Chapter III</strong> describes the development of the direct catalytic enantioselective conjugate addition of nitroalkanes to unactivated α,β-unsaturated esters, and the enantioselective synthesis of a range of APIs.</p>
<p><strong>Chapter IV</strong> discusses the NMR-aided pKBH+ measurements used to determine the basicity of iminophosphoranes. Furthermore, it describes a newly developed, analogous, but more rapid method for the determination of pKBH+ values, as well as the synthesis of a highly basic iminophosphorane.</p>
<p><strong>Chapter V</strong> contains the references for previous chapters. <strong>Chapter VI</strong> and <strong>Chapter VII</strong> contain the experimental details and analytical data of procedures and products described in <strong>Chapter II</strong> and <strong>Chapter III</strong>, and the <strong>Appendix</strong> contains synthetic information related to Chapter IV.</p> |
| first_indexed | 2024-09-25T04:18:10Z |
| format | Thesis |
| id | oxford-uuid:f672fae8-0dab-46f3-a2f2-32a31d7796d5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:18:10Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | oxford-uuid:f672fae8-0dab-46f3-a2f2-32a31d7796d52024-07-23T09:11:10ZDevelopment of bifunctional organic superbases for catalytic enantioselective synthesisThesishttp://purl.org/coar/resource_type/c_db06uuid:f672fae8-0dab-46f3-a2f2-32a31d7796d5Chemistry, OrganicEnantioselective catalysisHomogeneous catalysisEnglishHyrax Deposit2024Rozsar, DDixon, DFletcher, SPhipps, R<p><strong>Chapter I</strong> describes the concept of chirality and enantioselective synthesis. Organocatalysis is then introduced, with a focus on bifunctional organocatalysis and superbases in asymmetric methodology. Finally, bifunctional iminophosphorane catalysis is introduced and discussed.</p> <p><strong>Chapter II</strong> describes the development of the first organocatalytic conjugate addition to unactivated α,β-unsaturated amides, exemplified by a highly enantioselective sulfa-Michael addition, and along with that the development of 3rd generation BIMP catalysts.</p> <p><strong>Chapter III</strong> describes the development of the direct catalytic enantioselective conjugate addition of nitroalkanes to unactivated α,β-unsaturated esters, and the enantioselective synthesis of a range of APIs.</p> <p><strong>Chapter IV</strong> discusses the NMR-aided pKBH+ measurements used to determine the basicity of iminophosphoranes. Furthermore, it describes a newly developed, analogous, but more rapid method for the determination of pKBH+ values, as well as the synthesis of a highly basic iminophosphorane.</p> <p><strong>Chapter V</strong> contains the references for previous chapters. <strong>Chapter VI</strong> and <strong>Chapter VII</strong> contain the experimental details and analytical data of procedures and products described in <strong>Chapter II</strong> and <strong>Chapter III</strong>, and the <strong>Appendix</strong> contains synthetic information related to Chapter IV.</p> |
| spellingShingle | Chemistry, Organic Enantioselective catalysis Homogeneous catalysis Rozsar, D Development of bifunctional organic superbases for catalytic enantioselective synthesis |
| title | Development of bifunctional organic superbases for catalytic enantioselective synthesis |
| title_full | Development of bifunctional organic superbases for catalytic enantioselective synthesis |
| title_fullStr | Development of bifunctional organic superbases for catalytic enantioselective synthesis |
| title_full_unstemmed | Development of bifunctional organic superbases for catalytic enantioselective synthesis |
| title_short | Development of bifunctional organic superbases for catalytic enantioselective synthesis |
| title_sort | development of bifunctional organic superbases for catalytic enantioselective synthesis |
| topic | Chemistry, Organic Enantioselective catalysis Homogeneous catalysis |
| work_keys_str_mv | AT rozsard developmentofbifunctionalorganicsuperbasesforcatalyticenantioselectivesynthesis |