A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis

A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis

Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. Most patients present with early-stage disease, but a substantial proportion progress to myelofibrosis or secondary leukemia, advanced cancers with a poor prognosis and high symptom b...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Li, R, Colombo, M, Wang, G, Rodriguez-Romera, A, Benlabiod, C, Jooss, NJ, O'Sullivan, J, Brierley, CK, Clark, S-A, Pérez Sáez, JM, Fernández, PA, Schoof, EM, Porse, B, Meng, Y, Khan, AO, Wen, S, Dong, P, Zhou, W, Sousos, N, Murphy, L, Clarke, M, Olijnik, A-A, Wong, ZC, Karali, CS, Sirinukunwattana, K, Ryou, H, Norfo, R, Cheng, Q, Carrelha, J, Ren, Z, Thongjuea, S, Rathinam, VA, Krishnan, A, Royston, D, Rabinovich, GA, Mead, AJ, Psaila, B
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	American Association for the Advancement of Science 2024

Những quyển sách tương tự

Cross-talk between hematopoietic cells and fibroblast subsets drives inflammation and remodelling of the bone marrow microenvironment in myeloproliferative neoplasms
Bằng: Li, R, et al.
Được phát hành: (2022)

Rapid emergence of chronic lymphocytic leukemia during JAK2 inhibitor therapy in a patient with myelofibrosis
Bằng: Sousos, N, et al.
Được phát hành: (2020)

In utero origin of myelofibrosis presenting in adult monozygotic twins
Bằng: Sousos, N, et al.
Được phát hành: (2022)

Rapid Emergence of Chronic Lymphocytic Leukemia During JAK2 Inhibitor Therapy in a Patient With Myelofibrosis
Bằng: Nikolaos Sousos, et al.
Được phát hành: (2020-06-01)

Artificial intelligence-based morphological fingerprinting of megakaryocytes: a new tool for assessing disease in MPN patients
Bằng: Sirinukunwattana, K, et al.
Được phát hành: (2020)

Single-cell analyses reveal megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets
Bằng: Psaila, B, et al.
Được phát hành: (2020)

Continuous Indexing of Fibrosis (CIF): improving the assessment and classiﬁcation of MPN patients
Bằng: Harrington, H, et al.
Được phát hành: (2022)

Quantitative analysis of bone marrow fibrosis highlights heterogeneity in myelofibrosis and augments histological assessment: an insight from a phase II clinical study of zinpentraxin alfa
Bằng: Ryou, H, et al.
Được phát hành: (2024)

A single-cell approach to unraveling abnormal megakaryocyte differentiation and function in myelofibrosis
Bằng: Psaila, B, et al.
Được phát hành: (2017)

Application of single-cell approaches to study myeloproliferative neoplasm biology
Bằng: Royston, D, et al.
Được phát hành: (2021)

Processing single-cell RNA-seq datasets using SingCellaR
Bằng: Wang, G, et al.
Được phát hành: (2022)

Circulating Galectin-1 and Galectin-3 in Sera From Patients With Systemic Sclerosis: Associations With Clinical Features and Treatment
Bằng: Victoria Sundblad, et al.
Được phát hành: (2021-04-01)

Allogeneic Stem Cell Transplantation for Myelofibrosis in 2012
Bằng: Mclornan, D, et al.
Được phát hành: (2012)

Allogeneic stem cell transplantation for myelofibrosis in 2012.
Bằng: McLornan, D, et al.
Được phát hành: (2012)

Quantitative analysis of bone marrow fibrosis highlights heterogeneity in myelofibrosis and augments histological assessment: An Insight from a phase II clinical study of zinpentraxin alfa
Bằng: Hosuk Ryou, et al.
Được phát hành: (2024-06-01)

Galectins in Intestinal Inflammation: Galectin-1 Expression Delineates Response to Treatment in Celiac Disease Patients
Bằng: Victoria Sundblad, et al.
Được phát hành: (2018-03-01)

Unravelling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA sequencing
Bằng: Rodriguez-Meira, A, et al.
Được phát hành: (2019)

Guideline for the diagnosis and management of myelofibrosis
Bằng: Reilly, J, et al.
Được phát hành: (2012)

Guideline for the diagnosis and management of myelofibrosis.
Bằng: Reilly, J, et al.
Được phát hành: (2012)

Practical management of patients with myelofibrosis receiving ruxolitinib.
Bằng: Harrison, C, et al.
Được phát hành: (2013)

Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity
Bằng: Santiago P. Mendez-Huergo, et al.
Được phát hành: (2019-01-01)

Diagnosis and evaluation of prognosis of myelofibrosis: a British Society for Haematology Guideline
Bằng: McLornan, DP, et al.
Được phát hành: (2023)

Ruxolitinib is effective in patients with intermediate-1 risk myelofibrosis: a summary of recent evidence
Bằng: Harrison, C, et al.
Được phát hành: (2016)

Use of JAK inhibitors in the management of myelofibrosis: A revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012
Bằng: Reilly, J, et al.
Được phát hành: (2014)

Use of JAK inhibitors in the management of myelofibrosis: a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012.
Bằng: Reilly, J, et al.
Được phát hành: (2014)

The UK Myeloproliferative Neoplasm Registry for Myelofibrosis (UK-MPN-MF registry)
Bằng: Butt, N, et al.
Được phát hành: (2019)

“Galectin-1 Induces Central and Peripheral Cell Death:Implications in T-Cell Physiopathology”
Bằng: C. E. Sotomayor, et al.
Được phát hành: (2000-01-01)

Do galectins serve as soluble ligands for immune checkpoint receptors?
Bằng: Marco A Scheidegger, et al.
Được phát hành: (2024-04-01)

Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice
Bằng: Lysenko, V, et al.
Được phát hành: (2020)

Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation
Bằng: Psaila, B, et al.
Được phát hành: (2019)

"Time sweet time": circadian characterization of galectin-1 null mice
Bằng: Rabinovich Gabriel A, et al.
Được phát hành: (2010-04-01)

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution
Bằng: Rodriguez-Meira, A, et al.
Được phát hành: (2023)

Primary myelofibrosis in rheumatic diseases
Bằng: Vladimir Ivanovich Vasilyev, et al.
Được phát hành: (2013-04-01)

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.
Bằng: Di Genua, C, et al.
Được phát hành: (2019)

A tale of two alleles: TP53 and transformation in MPNs
Bằng: Brierley, C, et al.
Được phát hành: (2022)

Processing single-cell RNA-seq datasets using SingCellaR
Bằng: Guanlin Wang, et al.
Được phát hành: (2022-06-01)

A physician survey on the application of the British Society for Haematology guidelines for the diagnosis and management of myelofibrosis in the UK
Bằng: Harrison, C, et al.
Được phát hành: (2019)

Impaired antibody response to COVID-19 vaccination in patients with chronic myeloid neoplasms
Bằng: Chowdhury, O, et al.
Được phát hành: (2021)

Single cell RNA sequencing reveals molecular and functional platelet bias of aged hematopoietic stem cells
Bằng: Nerlov, C, et al.
Được phát hành: (2016)

Is it primary myelofibrosis or chronic megakaryocytic leukemia?
Bằng: Marshall A. Lichtman
Được phát hành: (2022-03-01)