A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis

A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis

Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. Most patients present with early-stage disease, but a substantial proportion progress to myelofibrosis or secondary leukemia, advanced cancers with a poor prognosis and high symptom b...

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Hauptverfasser: Li, R, Colombo, M, Wang, G, Rodriguez-Romera, A, Benlabiod, C, Jooss, NJ, O'Sullivan, J, Brierley, CK, Clark, S-A, Pérez Sáez, JM, Fernández, PA, Schoof, EM, Porse, B, Meng, Y, Khan, AO, Wen, S, Dong, P, Zhou, W, Sousos, N, Murphy, L, Clarke, M, Olijnik, A-A, Wong, ZC, Karali, CS, Sirinukunwattana, K, Ryou, H, Norfo, R, Cheng, Q, Carrelha, J, Ren, Z, Thongjuea, S, Rathinam, VA, Krishnan, A, Royston, D, Rabinovich, GA, Mead, AJ, Psaila, B
Format: Journal article
Sprache:English
Veröffentlicht: American Association for the Advancement of Science 2024

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