Evidence that the 5p12 variant rs10941679 confers susceptibility to estrogen receptor-positive breast cancer through FGF10 and MRPS30 regulation.

Evidence that the 5p12 variant rs10941679 confers susceptibility to estrogen receptor-positive breast cancer through FGF10 and MRPS30 regulation.

Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With...

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Auteurs principaux: Ghoussaini, M, French, J, Michailidou, K, Nord, S, Beesley, J, Canisus, S, Hillman, K, Kaufmann, S, Sivakumaran, H, Moradi Marjaneh, M, Lee, J, Dennis, J, Bolla, M, Wang, Q, Dicks, E, Milne, R, Hopper, J, Southey, M, Schmidt, M, Broeks, A, Muir, K, Lophatananon, A, Fasching, P, Beckmann, M, Fletcher, O, Johnson, N, Sawyer, E, Tomlinson, I, Burwinkel, B, Marme, F, Guénel, P, Truong, T, Bojesen, S, Flyger, H, Benitez, J, González-Neira, A, Alonso, M, Pita, G, Neuhausen, S, Anton-Culver, H, Brenner, H, Arndt, V, Meindl, A, Schmutzler, R, Brauch, H, Hamann, U, Tessier, D, Vincent, D, Nevanlinna, H, Khan, S, Matsuo, K, Ito, H, Dörk, T, Bogdanova, N, Lindblom, A, Margolin, S, Mannermaa, A, Kosma, V, Wu, A, Van Den Berg, D, Lambrechts, D, Floris, G, Chang-Claude, J, Rudolph, A, Radice, P, Barile, M, Couch, F, Hallberg, E, Giles, G, Haiman, C, Le Marchand, L, Goldberg, M, Teo, S, Yip, C, Borresen-Dale, A, Zheng, W, Cai, Q, Winqvist, R, Pylkäs, K, Andrulis, I, Devilee, P, Tollenaar, R, García-Closas, M, Figueroa, J, Hall, P, Czene, K, Brand, J, Darabi, H, Eriksson, M, Hooning, M, Koppert, L, Li, J, Shu, X, Zheng, Y, Cox, A, Cross, S, Shah, M, Rhenius, V, Choi, J, Kang, D, Hartman, M, Chia, K, Kabisch, M, Torres, D, Luccarini, C, Conroy, D, Jakubowska, A, Lubinski, J, Sangrajrang, S, Brennan, P, Olswold, C, Slager, S, Shen, C, Hou, M, Swerdlow, A, Schoemaker, M, Simard, J, Pharoah, P, Kristensen, V, Chenevix-Trench, G, Easton, D, Dunning, A, Edwards, S
Format: Journal article
Langue:English
Publié: Elsevier 2016

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