Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptib...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797104368119447552 |
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| author | Morris, A Voight, B Teslovich, T Ferreira, T Segrè, A Steinthorsdottir, V Strawbridge, R Khan, H Grallert, H Mahajan, A Prokopenko, I Kang, H Dina, C Esko, T Fraser, R Kanoni, S Kumar, A Lagou, V Langenberg, C Luan, J Lindgren, C Müller-Nurasyid, M Pechlivanis, S Rayner, N Scott, L |
| author_facet | Morris, A Voight, B Teslovich, T Ferreira, T Segrè, A Steinthorsdottir, V Strawbridge, R Khan, H Grallert, H Mahajan, A Prokopenko, I Kang, H Dina, C Esko, T Fraser, R Kanoni, S Kumar, A Lagou, V Langenberg, C Luan, J Lindgren, C Müller-Nurasyid, M Pechlivanis, S Rayner, N Scott, L |
| author_sort | Morris, A |
| collection | OXFORD |
| description | To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis. |
| first_indexed | 2024-03-07T06:32:51Z |
| format | Journal article |
| id | oxford-uuid:f69ae2c7-9699-4bde-bf69-3381946f4b7e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:32:51Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:f69ae2c7-9699-4bde-bf69-3381946f4b7e2022-03-27T12:36:22ZLarge-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f69ae2c7-9699-4bde-bf69-3381946f4b7eEnglishSymplectic Elements at Oxford2012Morris, AVoight, BTeslovich, TFerreira, TSegrè, ASteinthorsdottir, VStrawbridge, RKhan, HGrallert, HMahajan, AProkopenko, IKang, HDina, CEsko, TFraser, RKanoni, SKumar, ALagou, VLangenberg, CLuan, JLindgren, CMüller-Nurasyid, MPechlivanis, SRayner, NScott, LTo extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis. |
| spellingShingle | Morris, A Voight, B Teslovich, T Ferreira, T Segrè, A Steinthorsdottir, V Strawbridge, R Khan, H Grallert, H Mahajan, A Prokopenko, I Kang, H Dina, C Esko, T Fraser, R Kanoni, S Kumar, A Lagou, V Langenberg, C Luan, J Lindgren, C Müller-Nurasyid, M Pechlivanis, S Rayner, N Scott, L Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. |
| title | Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. |
| title_full | Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. |
| title_fullStr | Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. |
| title_full_unstemmed | Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. |
| title_short | Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. |
| title_sort | large scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes |
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