The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat
Avoidance, a hallmark of anxiety-related psychopathology, often comes at a cost; avoiding threat may forgo the possibility of a reward. Theories predict that optimal approach-avoidance arbitration depends on threat-induced psychophysiological states, like freezing-related bradycardia. Here we used m...
| Principais autores: | , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Nature Research
2024
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| _version_ | 1826313641867083776 |
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| author | Klaassen, FH de Voogd, LD Hulsman, AM O’Reilly, JX Klumpers, F Figner, B Roelofs, K |
| author_facet | Klaassen, FH de Voogd, LD Hulsman, AM O’Reilly, JX Klumpers, F Figner, B Roelofs, K |
| author_sort | Klaassen, FH |
| collection | OXFORD |
| description | Avoidance, a hallmark of anxiety-related psychopathology, often comes at a cost; avoiding threat may forgo the possibility of a reward. Theories predict that optimal approach-avoidance arbitration depends on threat-induced psychophysiological states, like freezing-related bradycardia. Here we used model-based fMRI analyses to investigate whether and how bradycardia states are linked to the neurocomputational underpinnings of approach-avoidance arbitration under varying reward and threat magnitudes. We show that bradycardia states are associated with increased threat-induced avoidance and more pronounced reward-threat value comparison (i.e., a stronger tendency to approach vs. avoid when expected reward outweighs threat). An amygdala-striatal-prefrontal circuit supports approach-avoidance arbitration under threat, with specific involvement of the amygdala and dorsal anterior cingulate (dACC) in integrating reward-threat value and bradycardia states. These findings highlight the role of human freezing states in value-based decision making, relevant for optimal threat coping. They point to a specific role for amygdala/dACC in state-value integration under threat. |
| first_indexed | 2024-09-25T04:18:10Z |
| format | Journal article |
| id | oxford-uuid:f6a30aa9-d7df-4c59-89d5-75c0cff9953c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:18:10Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:f6a30aa9-d7df-4c59-89d5-75c0cff9953c2024-07-20T16:10:08ZThe neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threatJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f6a30aa9-d7df-4c59-89d5-75c0cff9953cEnglishJisc Publications RouterNature Research2024Klaassen, FHde Voogd, LDHulsman, AMO’Reilly, JXKlumpers, FFigner, BRoelofs, KAvoidance, a hallmark of anxiety-related psychopathology, often comes at a cost; avoiding threat may forgo the possibility of a reward. Theories predict that optimal approach-avoidance arbitration depends on threat-induced psychophysiological states, like freezing-related bradycardia. Here we used model-based fMRI analyses to investigate whether and how bradycardia states are linked to the neurocomputational underpinnings of approach-avoidance arbitration under varying reward and threat magnitudes. We show that bradycardia states are associated with increased threat-induced avoidance and more pronounced reward-threat value comparison (i.e., a stronger tendency to approach vs. avoid when expected reward outweighs threat). An amygdala-striatal-prefrontal circuit supports approach-avoidance arbitration under threat, with specific involvement of the amygdala and dorsal anterior cingulate (dACC) in integrating reward-threat value and bradycardia states. These findings highlight the role of human freezing states in value-based decision making, relevant for optimal threat coping. They point to a specific role for amygdala/dACC in state-value integration under threat. |
| spellingShingle | Klaassen, FH de Voogd, LD Hulsman, AM O’Reilly, JX Klumpers, F Figner, B Roelofs, K The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat |
| title | The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat |
| title_full | The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat |
| title_fullStr | The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat |
| title_full_unstemmed | The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat |
| title_short | The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat |
| title_sort | neurocomputational link between defensive cardiac states and approach avoidance arbitration under threat |
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