Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.

Hepatocyte nuclear factor (HNF)-4alpha is part of a transcription factor network that is key for the development and function of the beta-cell. Rare mutations in the HNF4alpha gene cause maturity-onset diabetes of the young. A number of type 2 diabetes linkage studies have found evidence of linkage...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Weedon, M, Owen, K, Shields, B, Hitman, G, Walker, M, McCarthy, M, Love-Gregory, L, Permutt, M, Hattersley, A, Frayling, T
פורמט:	Journal article
שפה:	English
יצא לאור:	2004

פריטים דומים

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
מאת: Weedon, M, et al.
יצא לאור: (2005)

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
מאת: Weedon, M, et al.
יצא לאור: (2006)

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
מאת: Freathy, R, et al.
יצא לאור: (2006)

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
מאת: Edghill, E, et al.
יצא לאור: (2011)

The functional "KL-VS" variant of <it>KLOTHO </it>is not associated with type 2 diabetes in 5028 UK Caucasians
מאת: Walker Mark, et al.
יצא לאור: (2006-06-01)

Role of low frequency variants in HNF1A exons 8-10 encoding hepatocyte nuclear factor-1 alpha isoform A to susceptibility to Type 2 diabetes
מאת: Jafar-Mohammadi, B, et al.
יצא לאור: (2010)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
מאת: Freathy, R, et al.
יצא לאור: (2006)

Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
מאת: Mitchell, S, et al.
יצא לאור: (2003)

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
מאת: Patel, S, et al.
יצא לאור: (2006)

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
מאת: Zeggini, E, et al.
יצא לאור: (2005)

Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes
מאת: Groves, C, et al.
יצא לאור: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
מאת: Weedon, M, et al.
יצא לאור: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
מאת: Weedon, M, et al.
יצא לאור: (2006)

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
מאת: Groves, C, et al.
יצא לאור: (2006)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
מאת: Gloyn, A, et al.
יצא לאור: (2003)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
מאת: Gloyn, A, et al.
יצא לאור: (2003)

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
מאת: Owen, K, et al.
יצא לאור: (2004)

Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
מאת: Gloyn, A, et al.
יצא לאור: (2006)

Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
מאת: Freathy, R, et al.
יצא לאור: (2007)

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
מאת: Owen, K, et al.
יצא לאור: (2006)

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
מאת: Frayling, T, et al.
יצא לאור: (2003)

Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.
מאת: Barroso, I, et al.
יצא לאור: (2008)

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
מאת: Lango, H, et al.
יצא לאור: (2008)

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
מאת: Wiltshire, S, et al.
יצא לאור: (2002)

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
מאת: Wiltshire, S, et al.
יצא לאור: (2004)

Common variants in WFS1 confer risk of type 2 diabetes.
מאת: Sandhu, MS, et al.
יצא לאור: (2007)

Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach
מאת: Gloyn, A, et al.
יצא לאור: (2005)

Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
מאת: Zeggini, E, et al.
יצא לאור: (2004)

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
מאת: Zeggini, E, et al.
יצא לאור: (2004)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
מאת: Michael N Weedon, et al.
יצא לאור: (2006-10-01)

Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
מאת: Perry, JR, et al.
יצא לאור: (2009)

Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.
מאת: Mills, G, et al.
יצא לאור: (2004)

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
מאת: Pascoe, L, et al.
יצא לאור: (2007)

Fine-mapping type 2 diabetes causal variants on chromosome 9p21 in 2000 UK cases and 3000 unselected controls
מאת: Morris, A, et al.
יצא לאור: (2008)

The role of the HNF4alpha enhancer in type 2 diabetes.
מאת: Mitchell, S, et al.
יצא לאור: (2002)

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
מאת: Groves, C, et al.
יצא לאור: (2006)

Susceptibility for latent autoimmune diabetes in adults (LADA) is determined by variation at the 1DDM2 (insulin-gene) locus in white Caucasian patients from UK repositories
מאת: Desai, M, et al.
יצא לאור: (2005)

Assessment of the pathogenicity of the previously reported D526N Hepatocyte Nuclear factor-1 alpha (HNF1A) variant using a combined genetic, in silico and functional approach
מאת: Hassanali, N, et al.
יצא לאור: (2013)

Type 2 diabetes and the human homolog of the rat insulin resistance gene, CD36: No linkage or association in Europeans
מאת: McCarthy, M, et al.
יצא לאור: (1999)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes
מאת: Jafar-Mohammadi, B, et al.
יצא לאור: (2009)