Enantioselective silver-catalyzed cascade synthesis of fused lactone and lactam oxazolines
A new and highly stereoselective cascade reaction between isocyanoacetate esters and α-hydroxy and α-amino ketones has been developed. A cinchona alkaloid derived aminophosphine/silver(I) catalyst complex promoted the reaction and enabled the ready synthesis of fused bicyclic γ-lactone and γ-lactam...
| Hlavní autoři: | , , , , |
|---|---|
| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
American Chemical Society
2018
|
| Shrnutí: | A new and highly stereoselective cascade reaction between isocyanoacetate esters and α-hydroxy and α-amino ketones has been developed. A cinchona alkaloid derived aminophosphine/silver(I) catalyst complex promoted the reaction and enabled the ready synthesis of fused bicyclic γ-lactone and γ-lactam oxazolines with high enantiocontrol (up to 99% ee). |
|---|