High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals.

Using fluorescent HLA-A*0201 tetramers containing the immunodominant Melan-A/MART-1 (Melan-A) tumor-associated antigen (Ag), we previously observed that metastatic lymph nodes of melanoma patients contain high numbers of Ag-experienced Melan-A-specific cytolytic T lymphocytes (CTLs). In this paper,...

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Dettagli Bibliografici
Autori principali: Pittet, M, Valmori, D, Dunbar, P, Speiser, D, Liénard, D, Lejeune, F, Fleischhauer, K, Cerundolo, V, Cerottini, J, Romero, P
Natura: Journal article
Lingua:English
Pubblicazione: 1999