Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target?

Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target?

Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a multicomponent, nutrient-sensitive protein that is implicated in a wide range of major human diseases. mTORC1 responds to both growth factors and changes in local amino acid levels. Until recently, the intracellular amino acid-sensing mech...

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Bibliografiske detaljer
Hovedforfatter:	Goberdhan, D
Format:	Journal article
Sprog:	English
Udgivet:	2010

Lignende værker

Amino acid sensing by mTORC1: intracellular transporters mark the spot
af: Goberdhan, D, et al.
Udgivet: (2016)

Amino acid sensing by mTORC1: Intracellular transporters mark the spot.
af: Goberdhan, D, et al.
Udgivet: (2016)

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af: Bar-Peled, Liron
Udgivet: (2014)

Regulation of mTORC1 by amino acids
af: Bar-Peled, Liron, et al.
Udgivet: (2017)

Studies of amino acid sensing by the mTORC 1 pathway
af: Wang, Shuyu, Ph. D. Massachusetts Institute of Technology
Udgivet: (2017)

Mechanisms of amino acid sensing by the mTORC1 pathway
af: Saxton, Robert A. (Robert Andrew)
Udgivet: (2018)

Discovering regulators of the amino acid sensing pathway of mTORC1
af: Chantranupong, Lynne
Udgivet: (2017)

Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation.
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Udgivet: (2010)

The emerging role of mTORC1 signaling in placental nutrient-sensing.
af: Jansson, T, et al.
Udgivet: (2012)

The emerging role of mTORC1 signaling in placental nutrient-sensing
af: Jansson, T, et al.
Udgivet: (2012)

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af: Tsun, Zhi-Yang
Udgivet: (2015)

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af: Efeyan, Alejo, et al.
Udgivet: (2017)

Integration of amino acid signals by the mTORC1 pathway
af: Valenstein, Max L.
Udgivet: (2023)

Dynamics of mTORC1 activation in response to amino acids
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Udgivet: (2016-10-01)

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
af: Wolfson, Rachel Laura, et al.
Udgivet: (2018)

Rag proteins regulate amino-acid-induced mTORC1 signalling
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Udgivet: (2011)

Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
af: Meng-Zhu Li, et al.
Udgivet: (2022-07-01)

mTORC1 and mTORC2 Levels in Patients With Psoriasis
af: İlayda Esna Gülsunay, et al.
Udgivet: (2024-10-01)

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
af: Chantranupong, Lynne, et al.
Udgivet: (2015)

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
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Udgivet: (2014-10-01)

Anti-androgens regulate amino acid-mTORC1 signalling and extracellular vesicle secretion to modulate prostate cancer progression
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Udgivet: (2019)

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af: Kedir, Jibril F.
Udgivet: (2022)

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Udgivet: (2016)

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af: Chenglong Jin, et al.
Udgivet: (2024-08-01)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
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Udgivet: (2018-12-01)

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
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Udgivet: (2009-02-01)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
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Udgivet: (2016-10-01)

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma
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Udgivet: (2022-09-01)

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling
af: Mee-Sup Yoon, et al.
Udgivet: (2016-08-01)

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af: Liu, Grace Y.
Udgivet: (2023)

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af: Cangelosi, Andrew L.
Udgivet: (2022)

Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle
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Udgivet: (2017-05-01)

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
af: Sancak, Yasemin, et al.
Udgivet: (2012)

Regulation of nuclear mTORC1
af: Xin Zhou, et al.
Udgivet: (2021-05-01)

FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2
af: Koji Tsutsumi, et al.
Udgivet: (2023-12-01)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
af: Polina Kosillo, et al.
Udgivet: (2022-07-01)

mTORC1 and mTORC2 differentially promote natural killer cell development
af: Chao Yang, et al.
Udgivet: (2018-05-01)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
af: Jin Young Yang, et al.
Udgivet: (2019-06-01)

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
af: Zoncu, Roberto, et al.
Udgivet: (2015)

Regulation of Autophagy through TORC1 and mTORC1
af: Takeshi Noda
Udgivet: (2017-07-01)