Group B Streptococcal disease in England (1998 - 2017): a population-based observational study
<p><strong>Background and Objectives</strong> Group B Streptococcus (GBS) is the leading cause of sepsis and meningitis in infants <90 days. In this study, the burden of GBS disease and mortality in young infants in England was assessed.</p> <p><strong>Methods...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2020
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| _version_ | 1826305518267793408 |
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| author | Kadambari, S Trotter, CL Heath, PT Goldacre, MJ Pollard, AJ Goldacre, R |
| author_facet | Kadambari, S Trotter, CL Heath, PT Goldacre, MJ Pollard, AJ Goldacre, R |
| author_sort | Kadambari, S |
| collection | OXFORD |
| description | <p><strong>Background and Objectives</strong>
Group B Streptococcus (GBS) is the leading cause of sepsis and meningitis in infants <90 days. In this study, the burden of GBS disease and mortality in young infants in England was assessed.</p>
<p><strong>Methods</strong>
Using linked hospitalization records from every National Health Service (NHS) hospital from April 1, 1998 to March 31, 2017, we calculated annual GBS incidence in infants aged <90 days and, using regression models, compared their perinatal factors, rates of hospital-recorded disease outcomes, and all-cause infant mortality rates with those of the general infant population.</p>
<p><strong>Results</strong>
15 429 infants aged <90 days had a hospital-recorded diagnosis of GBS, giving an average annual incidence of 1.28 per 1000 live births (95% CI 1.26–1.30) with no significant trend over time. GBS-attributable mortality declined significantly from 0.044 (95% CI .029–.065) per 1000 live births in 2001 to 0.014 (95% CI .010–.026) in 2017 (annual percentage change −6.6, 95% CI −9.1 to −4.0). Infants with GBS had higher relative rates of visual impairment (HR 7.0 95% CI 4.1–12.1), cerebral palsy (HR 9.3 95% CI 6.6–13.3), hydrocephalus (HR 17.3 95% CI 13.8–21.6), and necrotizing enterocolitis (HR 18.8 95% CI 16.7–21.2) compared with those without GBS.</p>
<p><strong>Conclusions</strong>
Annual rates of GBS disease in infants have not changed over 19 years. The reduction in mortality is likely multifactorial and due to widespread implementation of antibiotics in at-risk mothers and babies, as well as advances in managing acutely unwell infants. New methods for prevention, such as maternal vaccination, must be prioritized.</p> |
| first_indexed | 2024-03-07T06:34:03Z |
| format | Journal article |
| id | oxford-uuid:f6fd8cea-6f6c-415f-af01-cd841e864bea |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:34:03Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:f6fd8cea-6f6c-415f-af01-cd841e864bea2022-03-27T12:39:20ZGroup B Streptococcal disease in England (1998 - 2017): a population-based observational studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f6fd8cea-6f6c-415f-af01-cd841e864beaEnglishSymplectic ElementsOxford University Press2020Kadambari, STrotter, CLHeath, PTGoldacre, MJPollard, AJGoldacre, R<p><strong>Background and Objectives</strong> Group B Streptococcus (GBS) is the leading cause of sepsis and meningitis in infants <90 days. In this study, the burden of GBS disease and mortality in young infants in England was assessed.</p> <p><strong>Methods</strong> Using linked hospitalization records from every National Health Service (NHS) hospital from April 1, 1998 to March 31, 2017, we calculated annual GBS incidence in infants aged <90 days and, using regression models, compared their perinatal factors, rates of hospital-recorded disease outcomes, and all-cause infant mortality rates with those of the general infant population.</p> <p><strong>Results</strong> 15 429 infants aged <90 days had a hospital-recorded diagnosis of GBS, giving an average annual incidence of 1.28 per 1000 live births (95% CI 1.26–1.30) with no significant trend over time. GBS-attributable mortality declined significantly from 0.044 (95% CI .029–.065) per 1000 live births in 2001 to 0.014 (95% CI .010–.026) in 2017 (annual percentage change −6.6, 95% CI −9.1 to −4.0). Infants with GBS had higher relative rates of visual impairment (HR 7.0 95% CI 4.1–12.1), cerebral palsy (HR 9.3 95% CI 6.6–13.3), hydrocephalus (HR 17.3 95% CI 13.8–21.6), and necrotizing enterocolitis (HR 18.8 95% CI 16.7–21.2) compared with those without GBS.</p> <p><strong>Conclusions</strong> Annual rates of GBS disease in infants have not changed over 19 years. The reduction in mortality is likely multifactorial and due to widespread implementation of antibiotics in at-risk mothers and babies, as well as advances in managing acutely unwell infants. New methods for prevention, such as maternal vaccination, must be prioritized.</p> |
| spellingShingle | Kadambari, S Trotter, CL Heath, PT Goldacre, MJ Pollard, AJ Goldacre, R Group B Streptococcal disease in England (1998 - 2017): a population-based observational study |
| title | Group B Streptococcal disease in England (1998 - 2017): a population-based observational study |
| title_full | Group B Streptococcal disease in England (1998 - 2017): a population-based observational study |
| title_fullStr | Group B Streptococcal disease in England (1998 - 2017): a population-based observational study |
| title_full_unstemmed | Group B Streptococcal disease in England (1998 - 2017): a population-based observational study |
| title_short | Group B Streptococcal disease in England (1998 - 2017): a population-based observational study |
| title_sort | group b streptococcal disease in england 1998 2017 a population based observational study |
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