Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution
Killer-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction, regulating hemochorial placentation. Uniquely among pri...
| Auteurs principaux: | , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
Springer Berlin Heidelberg
2016
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| _version_ | 1826305530450149376 |
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| author | Penman, B Moffett, A Chazara, O Gupta, S Parham, P |
| author_facet | Penman, B Moffett, A Chazara, O Gupta, S Parham, P |
| author_sort | Penman, B |
| collection | OXFORD |
| description | Killer-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure successful reproduction. Here we demonstrate that a combination of infectious disease selection and reproductive selection can drive the evolution of KIR B-like haplotypes from a KIR A-like founder haplotype. Continued selection to survive and to reproduce maintains a balance between KIR A and KIR B. |
| first_indexed | 2024-03-07T06:34:14Z |
| format | Journal article |
| id | oxford-uuid:f70d8c78-df6f-4a2d-9e9f-2af06feeb6b5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:34:14Z |
| publishDate | 2016 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | oxford-uuid:f70d8c78-df6f-4a2d-9e9f-2af06feeb6b52022-03-27T12:39:49ZReproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolutionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f70d8c78-df6f-4a2d-9e9f-2af06feeb6b5EnglishSymplectic Elements at OxfordSpringer Berlin Heidelberg2016Penman, BMoffett, AChazara, OGupta, SParham, PKiller-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure successful reproduction. Here we demonstrate that a combination of infectious disease selection and reproductive selection can drive the evolution of KIR B-like haplotypes from a KIR A-like founder haplotype. Continued selection to survive and to reproduce maintains a balance between KIR A and KIR B. |
| spellingShingle | Penman, B Moffett, A Chazara, O Gupta, S Parham, P Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution |
| title | Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution |
| title_full | Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution |
| title_fullStr | Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution |
| title_full_unstemmed | Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution |
| title_short | Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution |
| title_sort | reproduction infection and killer cell immunoglobulin like receptor haplotype evolution |
| work_keys_str_mv | AT penmanb reproductioninfectionandkillercellimmunoglobulinlikereceptorhaplotypeevolution AT moffetta reproductioninfectionandkillercellimmunoglobulinlikereceptorhaplotypeevolution AT chazarao reproductioninfectionandkillercellimmunoglobulinlikereceptorhaplotypeevolution AT guptas reproductioninfectionandkillercellimmunoglobulinlikereceptorhaplotypeevolution AT parhamp reproductioninfectionandkillercellimmunoglobulinlikereceptorhaplotypeevolution |