Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

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Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone N(ε)-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-c...

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Bibliographic Details
Main Authors: Thalhammer, A, Mecinović, J, Loenarz, C, Tumber, A, Rose, N, Heightman, T, Schofield, C
Format: Journal article
Language:English
Published: 2011
Subjects:
Molecular Structure
Humans
Models, Molecular
Jumonji Domain-Containing Histone Demethylases
Carboxylic Acids
antagonists and inhibitors
Catalysis
Structure-Activity Relationship
Pyridines
chemistry
pharmacology

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