Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Бусад хувилбаруудыг харуулах (1)

Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone N(ε)-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-c...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Thalhammer, A, Mecinović, J, Loenarz, C, Tumber, A, Rose, N, Heightman, T, Schofield, C
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2011
Нөхцлүүд:	Molecular Structure Humans Models, Molecular Jumonji Domain-Containing Histone Demethylases Carboxylic Acids antagonists and inhibitors Catalysis Structure-Activity Relationship Pyridines chemistry pharmacology

Ижил төстэй зүйлс

Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets
-н: Jeison Garcia, зэрэг
Хэвлэсэн: (2012-09-01)

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.
-н: Thalhammer, A, зэрэг
Хэвлэсэн: (2011)

The Jumonji family: past, present and future of histone demethylases in cancer
-н: Franci Gianluigi, зэрэг
Хэвлэсэн: (2014-06-01)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
-н: Kawamura, A, зэрэг
Хэвлэсэн: (2010)

The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays
-н: Jessica Lobo-Silva, зэрэг
Хэвлэсэн: (2020-03-01)

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
-н: Rose, N, зэрэг
Хэвлэсэн: (2010)

The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
-н: Jia Yang, зэрэг
Хэвлэсэн: (2022-04-01)

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors
-н: Maithili P. Dalvi, зэрэг
Хэвлэсэн: (2017-05-01)

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase
-н: Yue, W, зэрэг
Хэвлэсэн: (2010)

Histone demethylases in autophagy and inflammation
-н: Yaoyao Ma, зэрэг
Хэвлэсэн: (2025-01-01)

Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells
-н: Chongyang Shen, зэрэг
Хэвлэсэн: (2018-08-01)

Histone Lysine Demethylase JMJD2D/KDM4D and Family Members Mediate Effects of Chronic Social Defeat Stress on Mouse Hippocampal Neurogenesis and Mood Disorders
-н: Swati Maitra, зэрэг
Хэвлэсэн: (2020-11-01)

Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis
-н: Jinfeng Wu, зэрэг
Хэвлэсэн: (2020-11-01)

Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression
-н: Rashmi Srivastava, зэрэг
Хэвлэсэн: (2023-05-01)

Enterotoxigenic Bacteroides fragilis induces the stemness in colorectal cancer via upregulating histone demethylase JMJD2B
-н: Qian-Qian Liu, зэрэг
Хэвлэсэн: (2020-11-01)

Relationship between histone demethylase LSD family and development and prognosis of gastric cancer
-н: Liyan Dong, зэрэг
Хэвлэсэн: (2023-05-01)

Zn-ejection for the selective inhibition of JMJD2 histone demethylases
-н: Sekirnik, R, зэрэг
Хэвлэсэн: (2012)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
-н: Sakurai, M, зэрэг
Хэвлэсэн: (2010)

Exploring the substrate scope of histone demethylases
-н: Bonnici, J
Хэвлэсэн: (2020)

Histone Methylases and Demethylases Regulating Antagonistic Methyl Marks: Changes Occurring in Cancer
-н: Joyce Taylor-Papadimitriou, зэрэг
Хэвлэсэн: (2022-03-01)

JmjC histone demethylases act as chromatin oxygen sensors
-н: Michael Batie, зэрэг
Хэвлэсэн: (2019-07-01)

Removal of H3K27me3 by JMJ Proteins Controls Plant Development and Environmental Responses in Arabidopsis
-н: Nobutoshi Yamaguchi
Хэвлэсэн: (2021-06-01)

Histone demethylase JMJD1C promotes the polarization of M1 macrophages to prevent glioma by upregulating miR‐302a
-н: Chuanhong Zhong, зэрэг
Хэвлэсэн: (2021-09-01)

Therapeutic Potentials of Inhibition of Jumonji C Domaincontaining Demethylases in Acute Myeloid Leukemia
-н: Duygu Koca, зэрэг
Хэвлэсэн: (2020-02-01)

Histone Demethylases ELF6 and JMJ13 Antagonistically Regulate Self-Fertility in Arabidopsis
-н: Charlie Keyzor, зэрэг
Хэвлэсэн: (2021-02-01)

The emerging role of histone lysine demethylases in prostate cancer
-н: Crea Francesco, зэрэг
Хэвлэсэн: (2012-08-01)

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).
-н: Sekirnik, R, зэрэг
Хэвлэсэн: (2009)

The Four FAD-Dependent Histone Demethylases of Arabidopsis Are Differently Involved in the Control of Flowering Time
-н: Damiano Martignago, зэрэг
Хэвлэсэн: (2019-06-01)

The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells
-н: Ziyu Zhang, зэрэг
Хэвлэсэн: (2021-06-01)

Analysis on Cloning and Expression of Histone Demethylase Gene OsJMJ719 in Rice
-н: Junting JIA, зэрэг
Хэвлэсэн: (2022-11-01)

Corrigendum: The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells
-н: Ziyu Zhang, зэрэг
Хэвлэсэн: (2021-07-01)

Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM2B
-н: Mikkel Staberg, зэрэг
Хэвлэсэн: (2018-03-01)

The Novel Protease Activities of JMJD5–JMJD6–JMJD7 and Arginine Methylation Activities of Arginine Methyltransferases Are Likely Coupled
-н: Haolin Liu, зэрэг
Хэвлэсэн: (2022-02-01)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
-н: Rose, N, зэрэг
Хэвлэсэн: (2008)

Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile
-н: Hideaki Niwa, зэрэг
Хэвлэсэн: (2018-06-01)

MoJMJ1, Encoding a Histone Demethylase Containing JmjC Domain, Is Required for Pathogenic Development of the Rice Blast Fungus, Magnaporthe oryzae
-н: Aram Huh, зэрэг
Хэвлэсэн: (2017-04-01)

Arabidopsis Histone Demethylases LDL1 and LDL2 Control Primary Seed Dormancy by Regulating DELAY OF GERMINATION 1 and ABA Signaling-Related Genes
-н: Ming lei Zhao
Хэвлэсэн: (2015-03-01)

JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers
-н: Maithili P. Dalvi, зэрэг
Хэвлэсэн: (2017-09-01)

Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
-н: Yishu Wang, зэрэг
Хэвлэсэн: (2020-04-01)

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
-н: Marc A Kerenyi, зэрэг
Хэвлэсэн: (2013-06-01)