Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

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Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone N(ε)-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-c...

书目详细资料
Main Authors:	Thalhammer, A, Mecinović, J, Loenarz, C, Tumber, A, Rose, N, Heightman, T, Schofield, C
格式:	Journal article
语言:	English
出版:	2011
主题:	Molecular Structure Humans Models, Molecular Jumonji Domain-Containing Histone Demethylases Carboxylic Acids antagonists and inhibitors Catalysis Structure-Activity Relationship Pyridines chemistry pharmacology

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