The global burden of sepsis: barriers and potential solutions
Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, pover...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2018
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| _version_ | 1797104476359753728 |
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| author | Rudd, KE Kissoon, N Limmathurotsakul, D Bory, S Mutahunga, B Seymour, CW Angus, DC West, TE |
| author_facet | Rudd, KE Kissoon, N Limmathurotsakul, D Bory, S Mutahunga, B Seymour, CW Angus, DC West, TE |
| author_sort | Rudd, KE |
| collection | OXFORD |
| description | Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy. |
| first_indexed | 2024-03-07T06:34:21Z |
| format | Journal article |
| id | oxford-uuid:f7169c00-868d-4eee-9dda-6049b926fde9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:34:21Z |
| publishDate | 2018 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:f7169c00-868d-4eee-9dda-6049b926fde92022-03-27T12:40:05ZThe global burden of sepsis: barriers and potential solutionsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f7169c00-868d-4eee-9dda-6049b926fde9EnglishSymplectic Elements at OxfordBioMed Central2018Rudd, KEKissoon, NLimmathurotsakul, DBory, SMutahunga, BSeymour, CWAngus, DCWest, TESepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy. |
| spellingShingle | Rudd, KE Kissoon, N Limmathurotsakul, D Bory, S Mutahunga, B Seymour, CW Angus, DC West, TE The global burden of sepsis: barriers and potential solutions |
| title | The global burden of sepsis: barriers and potential solutions |
| title_full | The global burden of sepsis: barriers and potential solutions |
| title_fullStr | The global burden of sepsis: barriers and potential solutions |
| title_full_unstemmed | The global burden of sepsis: barriers and potential solutions |
| title_short | The global burden of sepsis: barriers and potential solutions |
| title_sort | global burden of sepsis barriers and potential solutions |
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