Common variants at 11p13 are associated with susceptibility to tuberculosis

Common variants at 11p13 are associated with susceptibility to tuberculosis

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After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (...

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Κύριοι συγγραφείς: Thye, T, Owusu-Dabo, E, Vannberg, F, Van Crevel, R, Curtis, J, Sahiratmadja, E, Balabanova, Y, Ehmen, C, Muntau, B, Ruge, G, Sievertsen, J, Gyapong, J, Nikolayevskyy, V, Hill, P, Sirugo, G, Drobniewski, F, Van De Vosse, E, Newport, M, Alisjahbana, B, Nejentsev, S, Ottenhoff, T, Hill, A, Horstmann, R, Meyer, C
Μορφή: Journal article
Γλώσσα:English
Έκδοση: 2012
Περιγραφή
Περίληψη:After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10 -9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10 -11. © 2012 Nature America, Inc. All rights reserved.

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