Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity.
<h4>Introduction</h4> <p>Given the expected increase in the number of patients with osteoporosis and fragility fractures it is important to have concise information on trends in prescription rates of anti-osteoporosis drugs (AOD).</p> <h4>Methods</h4> <p>We...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2016
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| _version_ | 1797104498535038976 |
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| author | van der Velde, R Wyers, C Teesselink, E Geusens, P van den Bergh, J de Vries, F Cooper, C Harvey, N van Staa, T |
| author_facet | van der Velde, R Wyers, C Teesselink, E Geusens, P van den Bergh, J de Vries, F Cooper, C Harvey, N van Staa, T |
| author_sort | van der Velde, R |
| collection | OXFORD |
| description | <h4>Introduction</h4> <p>Given the expected increase in the number of patients with osteoporosis and fragility fractures it is important to have concise information on trends in prescription rates of anti-osteoporosis drugs (AOD).</p> <h4>Methods</h4> <p>We undertook a retrospective observational study using the UK Clinical Practice Research Datalink (CPRD) in the UK between 1990 and 2012 in subjects 50 years or older, stratified by age, sex, geographic region and ethnicity. Yearly prescription incidence rates of any AOD and of each specific AOD were calculated as the number of patients first prescribed these AODs per 10,000 person-years (py).</p> <h4>Results</h4> <p>In women, yearly rates of first prescription of any AOD increased from 1990-2006 (from 2.3 to 169.7 per 10,000 py), followed by a plateau and a 12% decrease in the last three years. In men, a less steep increase from 1990-2007 (from 1.4 to 45.3 per 10,000 py) was followed by a plateau from 2008 onwards. Yearly rates of first prescription of any AOD increased up to the age of 85-89 years (248.9 per 10,000 py in women and 119.3 in men). There were marked differences between ethnic groups and regions. Bisphosphonates were the most frequently prescribed AODs: etidronate till 2000, and then subsequently alendronate.</p> <h4>Conclusion</h4> <p>We have demonstrated marked secular changes in rates of anti-osteoporosis drug prescription over the last two decades. The plateau (and decrease amongst women) in rates in recent years, set against an ever ageing population is worrying, suggesting that the well-documented care gap in osteoporosis treatment persists. The differences in prescription rates by geographic location and ethnicity raise intriguing questions in relation to underlying fracture rates, provision of care and health behaviour.</p> |
| first_indexed | 2024-03-07T06:34:35Z |
| format | Journal article |
| id | oxford-uuid:f72940b4-d6c9-4628-bfeb-426e021a467f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:34:35Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:f72940b4-d6c9-4628-bfeb-426e021a467f2022-03-27T12:40:46ZTrends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f72940b4-d6c9-4628-bfeb-426e021a467fEnglishSymplectic Elements at OxfordElsevier2016van der Velde, RWyers, CTeesselink, EGeusens, Pvan den Bergh, Jde Vries, FCooper, CHarvey, Nvan Staa, T <h4>Introduction</h4> <p>Given the expected increase in the number of patients with osteoporosis and fragility fractures it is important to have concise information on trends in prescription rates of anti-osteoporosis drugs (AOD).</p> <h4>Methods</h4> <p>We undertook a retrospective observational study using the UK Clinical Practice Research Datalink (CPRD) in the UK between 1990 and 2012 in subjects 50 years or older, stratified by age, sex, geographic region and ethnicity. Yearly prescription incidence rates of any AOD and of each specific AOD were calculated as the number of patients first prescribed these AODs per 10,000 person-years (py).</p> <h4>Results</h4> <p>In women, yearly rates of first prescription of any AOD increased from 1990-2006 (from 2.3 to 169.7 per 10,000 py), followed by a plateau and a 12% decrease in the last three years. In men, a less steep increase from 1990-2007 (from 1.4 to 45.3 per 10,000 py) was followed by a plateau from 2008 onwards. Yearly rates of first prescription of any AOD increased up to the age of 85-89 years (248.9 per 10,000 py in women and 119.3 in men). There were marked differences between ethnic groups and regions. Bisphosphonates were the most frequently prescribed AODs: etidronate till 2000, and then subsequently alendronate.</p> <h4>Conclusion</h4> <p>We have demonstrated marked secular changes in rates of anti-osteoporosis drug prescription over the last two decades. The plateau (and decrease amongst women) in rates in recent years, set against an ever ageing population is worrying, suggesting that the well-documented care gap in osteoporosis treatment persists. The differences in prescription rates by geographic location and ethnicity raise intriguing questions in relation to underlying fracture rates, provision of care and health behaviour.</p> |
| spellingShingle | van der Velde, R Wyers, C Teesselink, E Geusens, P van den Bergh, J de Vries, F Cooper, C Harvey, N van Staa, T Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity. |
| title | Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity. |
| title_full | Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity. |
| title_fullStr | Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity. |
| title_full_unstemmed | Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity. |
| title_short | Trends in oral anti-osteoporosis drug prescription in the United Kingdom between 1990 and 2012: Variation by age, sex, geographic location and ethnicity. |
| title_sort | trends in oral anti osteoporosis drug prescription in the united kingdom between 1990 and 2012 variation by age sex geographic location and ethnicity |
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