Pleasure systems in the brain
Pleasure is mediated by well-developed mesocorticolimbic circuitry and serves adaptive functions. In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affect) can result from breakdowns of that hedonic system. Human neuroimaging studies indicate that surprisingly similar circu...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2016
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| _version_ | 1797104517643239424 |
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| author | Berridge, K Kringelbach, M |
| author_facet | Berridge, K Kringelbach, M |
| author_sort | Berridge, K |
| collection | OXFORD |
| description | Pleasure is mediated by well-developed mesocorticolimbic circuitry and serves adaptive functions. In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affect) can result from breakdowns of that hedonic system. Human neuroimaging studies indicate that surprisingly similar circuitry is activated by quite diverse pleasures, suggesting a common neural currency shared by all. Wanting for reward is generated by a large and distributed brain system. Liking, or pleasure itself, is generated by a smaller set of hedonic hot spots within limbic circuitry. Those hot spots also can be embedded in broader anatomical patterns of valence organization, such as in a keyboard pattern of nucleus accumbens generators for desire versus dread. In contrast, some of the best known textbook candidates for pleasure generators, including classic pleasure electrodes and the mesolimbic dopamine system, may not generate pleasure after all. These emerging insights into brain pleasure mechanisms may eventually facilitate better treatments for affective disorders. |
| first_indexed | 2024-03-07T06:34:52Z |
| format | Journal article |
| id | oxford-uuid:f73f9635-7fd9-4508-975b-7a326b0649b1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:34:52Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:f73f9635-7fd9-4508-975b-7a326b0649b12022-03-27T12:41:25ZPleasure systems in the brainJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f73f9635-7fd9-4508-975b-7a326b0649b1EnglishSymplectic Elements at OxfordElsevier2016Berridge, KKringelbach, MPleasure is mediated by well-developed mesocorticolimbic circuitry and serves adaptive functions. In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affect) can result from breakdowns of that hedonic system. Human neuroimaging studies indicate that surprisingly similar circuitry is activated by quite diverse pleasures, suggesting a common neural currency shared by all. Wanting for reward is generated by a large and distributed brain system. Liking, or pleasure itself, is generated by a smaller set of hedonic hot spots within limbic circuitry. Those hot spots also can be embedded in broader anatomical patterns of valence organization, such as in a keyboard pattern of nucleus accumbens generators for desire versus dread. In contrast, some of the best known textbook candidates for pleasure generators, including classic pleasure electrodes and the mesolimbic dopamine system, may not generate pleasure after all. These emerging insights into brain pleasure mechanisms may eventually facilitate better treatments for affective disorders. |
| spellingShingle | Berridge, K Kringelbach, M Pleasure systems in the brain |
| title | Pleasure systems in the brain |
| title_full | Pleasure systems in the brain |
| title_fullStr | Pleasure systems in the brain |
| title_full_unstemmed | Pleasure systems in the brain |
| title_short | Pleasure systems in the brain |
| title_sort | pleasure systems in the brain |
| work_keys_str_mv | AT berridgek pleasuresystemsinthebrain AT kringelbachm pleasuresystemsinthebrain |