Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization.
Alpha,omega-diphosphonic acids self-assemble on the native oxide surfaces of Ti or Ti-6Al-4V. Heating gives strongly bonded phosphonate monolayers. Infrared and X-ray spectroscopic and water contact angle data show that the films are bonded to the surface by one phosphonate unit; the other remains a...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797104530624610304 |
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| author | Danahy, M Avaltroni, M Midwood, K Schwarzbauer, J Schwartz, J |
| author_facet | Danahy, M Avaltroni, M Midwood, K Schwarzbauer, J Schwartz, J |
| author_sort | Danahy, M |
| collection | OXFORD |
| description | Alpha,omega-diphosphonic acids self-assemble on the native oxide surfaces of Ti or Ti-6Al-4V. Heating gives strongly bonded phosphonate monolayers. Infrared and X-ray spectroscopic and water contact angle data show that the films are bonded to the surface by one phosphonate unit; the other remains a phosphonic acid. Surface loadings were measured by quartz crystal microbalance procedures. Mechanical shear strengths for the films were also measured; these do not correlate simply with surface loadings. Films formed from 1,12-diphosphonododecane were treated with zirconium tetra(tert-butoxide) to give surface Zr complex species; derivatives of these surface complexes are stable to hydrolysis under physiological conditions and are mechanically strong. The complexation reaction can be accomplished over the entire surface; alternatively, dropwise application of the alkoxide to the surface enables spatial control of deposition. The cell attractive peptide derivative RGDC can be bound to these surface Zr alkoxide complexes through (maleimido)-alkylcarboxylate intermediates. Surfaces modified with RGDC were shown to be effective for osteoblast binding and proliferation. |
| first_indexed | 2024-03-07T06:35:03Z |
| format | Journal article |
| id | oxford-uuid:f7530ae2-7c3d-42fb-a1d3-7c3d1b8dacb4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:35:03Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:f7530ae2-7c3d-42fb-a1d3-7c3d1b8dacb42022-03-27T12:41:54ZSelf-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f7530ae2-7c3d-42fb-a1d3-7c3d1b8dacb4EnglishSymplectic Elements at Oxford2004Danahy, MAvaltroni, MMidwood, KSchwarzbauer, JSchwartz, JAlpha,omega-diphosphonic acids self-assemble on the native oxide surfaces of Ti or Ti-6Al-4V. Heating gives strongly bonded phosphonate monolayers. Infrared and X-ray spectroscopic and water contact angle data show that the films are bonded to the surface by one phosphonate unit; the other remains a phosphonic acid. Surface loadings were measured by quartz crystal microbalance procedures. Mechanical shear strengths for the films were also measured; these do not correlate simply with surface loadings. Films formed from 1,12-diphosphonododecane were treated with zirconium tetra(tert-butoxide) to give surface Zr complex species; derivatives of these surface complexes are stable to hydrolysis under physiological conditions and are mechanically strong. The complexation reaction can be accomplished over the entire surface; alternatively, dropwise application of the alkoxide to the surface enables spatial control of deposition. The cell attractive peptide derivative RGDC can be bound to these surface Zr alkoxide complexes through (maleimido)-alkylcarboxylate intermediates. Surfaces modified with RGDC were shown to be effective for osteoblast binding and proliferation. |
| spellingShingle | Danahy, M Avaltroni, M Midwood, K Schwarzbauer, J Schwartz, J Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. |
| title | Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. |
| title_full | Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. |
| title_fullStr | Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. |
| title_full_unstemmed | Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. |
| title_short | Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. |
| title_sort | self assembled monolayers of alpha omega diphosphonic acids on ti enable complete or spatially controlled surface derivatization |
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