Factors associated with COVID-19-related death using OpenSAFELY
Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, and this requires new approaches for the timely analysis of large datasets. Working on behalf of NHS England, we created OpenSAFELY—a se...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2020
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| _version_ | 1797104544908312576 |
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| author | Williamson, EJ Walker, AJ Bhaskaran, K Bacon, S Bates, C Morton, CE Curtis, HJ Mehrkar, A Evans, D Inglesby, P Cockburn, J McDonald, HI MacKenna, B Tomlinson, L Douglas, IJ Rentsch, CT Mathur, R Wong, AYS Grieve, R Harrison, D Forbes, H Schultze, A Croker, R Parry, J Hester, F Harper, S Perera, R Evans, SJW Smeeth, L Goldacre, B |
| author_facet | Williamson, EJ Walker, AJ Bhaskaran, K Bacon, S Bates, C Morton, CE Curtis, HJ Mehrkar, A Evans, D Inglesby, P Cockburn, J McDonald, HI MacKenna, B Tomlinson, L Douglas, IJ Rentsch, CT Mathur, R Wong, AYS Grieve, R Harrison, D Forbes, H Schultze, A Croker, R Parry, J Hester, F Harper, S Perera, R Evans, SJW Smeeth, L Goldacre, B |
| author_sort | Williamson, EJ |
| collection | OXFORD |
| description | Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, and this requires new approaches for the timely analysis of large datasets. Working on behalf of NHS England, we created OpenSAFELY—a secure health analytics platform that covers 40% of all patients in England and holds patient data within the existing data centre of a major vendor of primary care electronic health records. Here we used OpenSAFELY to examine factors associated with COVID-19-related death. Primary care records of 17,278,392 adults were pseudonymously linked to 10,926 COVID-19-related deaths. COVID-19-related death was associated with: being male (hazard ratio (HR) 1.59 (95% confidence interval 1.53–1.65)); greater age and deprivation (both with a strong gradient); diabetes; severe asthma; and various other medical conditions. Compared with people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors (HR 1.48 (1.29–1.69) and 1.45 (1.32–1.58), respectively). We have quantified a range of clinical factors associated with COVID-19-related death in one of the largest cohort studies on this topic so far. More patient records are rapidly being added to OpenSAFELY, we will update and extend our results regularly. |
| first_indexed | 2024-03-07T06:35:16Z |
| format | Journal article |
| id | oxford-uuid:f768b00f-0271-4fa0-a771-16eeac27c850 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:35:16Z |
| publishDate | 2020 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:f768b00f-0271-4fa0-a771-16eeac27c8502022-03-27T12:42:38ZFactors associated with COVID-19-related death using OpenSAFELYJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f768b00f-0271-4fa0-a771-16eeac27c850EnglishSymplectic ElementsSpringer Nature2020Williamson, EJWalker, AJBhaskaran, KBacon, SBates, CMorton, CECurtis, HJMehrkar, AEvans, DInglesby, PCockburn, JMcDonald, HIMacKenna, BTomlinson, LDouglas, IJRentsch, CTMathur, RWong, AYSGrieve, RHarrison, DForbes, HSchultze, ACroker, RParry, JHester, FHarper, SPerera, REvans, SJWSmeeth, LGoldacre, BCoronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, and this requires new approaches for the timely analysis of large datasets. Working on behalf of NHS England, we created OpenSAFELY—a secure health analytics platform that covers 40% of all patients in England and holds patient data within the existing data centre of a major vendor of primary care electronic health records. Here we used OpenSAFELY to examine factors associated with COVID-19-related death. Primary care records of 17,278,392 adults were pseudonymously linked to 10,926 COVID-19-related deaths. COVID-19-related death was associated with: being male (hazard ratio (HR) 1.59 (95% confidence interval 1.53–1.65)); greater age and deprivation (both with a strong gradient); diabetes; severe asthma; and various other medical conditions. Compared with people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors (HR 1.48 (1.29–1.69) and 1.45 (1.32–1.58), respectively). We have quantified a range of clinical factors associated with COVID-19-related death in one of the largest cohort studies on this topic so far. More patient records are rapidly being added to OpenSAFELY, we will update and extend our results regularly. |
| spellingShingle | Williamson, EJ Walker, AJ Bhaskaran, K Bacon, S Bates, C Morton, CE Curtis, HJ Mehrkar, A Evans, D Inglesby, P Cockburn, J McDonald, HI MacKenna, B Tomlinson, L Douglas, IJ Rentsch, CT Mathur, R Wong, AYS Grieve, R Harrison, D Forbes, H Schultze, A Croker, R Parry, J Hester, F Harper, S Perera, R Evans, SJW Smeeth, L Goldacre, B Factors associated with COVID-19-related death using OpenSAFELY |
| title | Factors associated with COVID-19-related death using OpenSAFELY |
| title_full | Factors associated with COVID-19-related death using OpenSAFELY |
| title_fullStr | Factors associated with COVID-19-related death using OpenSAFELY |
| title_full_unstemmed | Factors associated with COVID-19-related death using OpenSAFELY |
| title_short | Factors associated with COVID-19-related death using OpenSAFELY |
| title_sort | factors associated with covid 19 related death using opensafely |
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