Signalling cross talk of the HIF system: involvement of the FIH protein.

Signalling cross talk of the HIF system: involvement of the FIH protein.

Cellular and systemic oxygen homeostasis is regulated by an oxygen-sensitive signalling pathway centred on a transcription factor known as Hypoxia Inducible Factor (HIF). Regulation of HIF activity and protein stability is mediated by a family of hydroxylases that act as oxygen sensors due to the de...

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Bibliografiske detaljer
Main Authors:	Coleman, M, Ratcliffe, P
Format:	Journal article
Sprog:	English
Udgivet:	2009

Lignende værker

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
af: Cockman, M, et al.
Udgivet: (2006)

Factor inhibiting HIF (FIH1) modulates cardiac function and metabolism
af: Holliday, J, et al.
Udgivet: (2018)

Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively
af: Wang, Y, et al.
Udgivet: (2018)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
af: Masson, N, et al.
Udgivet: (2012)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
af: Masson, N, et al.
Udgivet: (2012)

Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis
af: Ma, J
Udgivet: (2017)

Factor-inhibiting HIF (FIH) promotes lung cancer progression
af: Ana García-del Río, et al.
Udgivet: (2023-10-01)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
af: Hewitson, K, et al.
Udgivet: (2002)

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
af: Cockman, M, et al.
Udgivet: (2009)

The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme.
af: Enfeng Wang, et al.
Udgivet: (2014-01-01)

Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival
af: Kiriakidis, S, et al.
Udgivet: (2015)

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.
af: Khan, M, et al.
Udgivet: (2011)

FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1α
af: Jengmin Kang, et al.
Udgivet: (2018-10-01)

Studies on FIH interactions
af: Leissing, T
Udgivet: (2017)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
af: Stolze, I, et al.
Udgivet: (2004)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
af: Hewitson, K, et al.
Udgivet: (2008)

Fih attenuates the hypoxic tolerance of Megalobrama amblycephala by inhibiting the activity of hypoxia-inducible factor alpha (hif-α)
af: Jun Li, et al.
Udgivet: (2024-08-01)

ceRNA regulatory network of FIH inhibitor as a radioprotector for gastrointestinal toxicity by activating the HIF-1 pathway
af: Yu-wei Yang, et al.
Udgivet: (2021-09-01)

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
af: Webb, J, et al.
Udgivet: (2009)

Signalling hypoxia by HIF hydroxylases.
af: Schofield, C, et al.
Udgivet: (2005)

Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival.
af: Sigve Andersen, et al.
Udgivet: (2011-01-01)

La verità, vi prego, sul criterio del creditore privato: Commissione c. FIH Holding e FIH Erhvervsbank
af: Alessandro Rosanò
Udgivet: (2019-03-01)

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
af: Lancaster, D, et al.
Udgivet: (2004)

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
af: Cockman, M, et al.
Udgivet: (2009)

Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway.
af: Giatromanolaki, A, et al.
Udgivet: (2008)

Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway
af: Giatromanolaki, A, et al.
Udgivet: (2008)

Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1
af: Christina Pickel, et al.
Udgivet: (2019-09-01)

HIF-1 and HIF-2: working alone or together in hypoxia?
af: Ratcliffe, P
Udgivet: (2007)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
af: Lancaster, D, et al.
Udgivet: (2004)

Targeting tumors through the HIF system.
af: Ratcliffe, P, et al.
Udgivet: (2000)

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
af: Carsten C Scholz, et al.
Udgivet: (2016-01-01)

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
af: Yang, M, et al.
Udgivet: (2011)

Regulation of angiogenesis by hypoxia: role of the HIF system.
af: Pugh, C, et al.
Udgivet: (2003)

The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia
af: Pia M. Vidal, et al.
Udgivet: (2020-03-01)

Novel insights into FH-associated disease are KEAPing the lid on oncogenic HIF signalling.
af: Adam, J, et al.
Udgivet: (2011)

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
af: Banerji, B, et al.
Udgivet: (2005)

ExCITED about HIF.
af: Bhattacharya, S, et al.
Udgivet: (2003)

The HIF hydroxylase pathway and the tumour microenvironment
af: Ratcliffe, P
Udgivet: (2008)

Oxygen sensing by HIF hydroxylases.
af: Schofield, C, et al.
Udgivet: (2004)

Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis
af: Azael Torales-Cardeña, et al.
Udgivet: (2015-01-01)