Signalling cross talk of the HIF system: involvement of the FIH protein.

Cellular and systemic oxygen homeostasis is regulated by an oxygen-sensitive signalling pathway centred on a transcription factor known as Hypoxia Inducible Factor (HIF). Regulation of HIF activity and protein stability is mediated by a family of hydroxylases that act as oxygen sensors due to the de...

Полное описание

Библиографические подробности
Главные авторы: Coleman, M, Ratcliffe, P
Формат: Journal article
Язык:English
Опубликовано: 2009