Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors.

Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors.

It has been proposed that antibodies can mimic the binding of a receptor to its ligand and that anti-idiotype antibodies raised against such antibodies can be used to identify the receptor. A large number of antibodies have been raised against CD4, the receptor on T cells for the envelope glycoprote...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Davis, S, Schockmel, G, Somoza, C, Buck, D, Healey, D, Rieber, E, Reiter, C, Williams, A
Materialtyp:	Journal article
Språk:	English
Publicerad:	1992

Liknande verk

The recognition of chimeras of rat and human CD4 by HIV-1 gp120 and by monoclonal antibodies.
av: Davis, S, et al.
Publicerad: (1993)

Construction of a binding site for human immunodeficiency virus type 1 gp120 in rat CD4.
av: Schockmel, G, et al.
Publicerad: (1992)

A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection.
av: Simon, J, et al.
Publicerad: (1993)

Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response
av: Hioe Catarina E, et al.
Publicerad: (2008-07-01)

Fusion Complexes and CD4-independent gp120s for the Induction of HIV-1 Neutralizing Antibodies
av: Lopalco L, et al.
Publicerad: (2005-12-01)

Role of anti-CD4-binding site antibodies in modulating gp120-specific CD4 T cell and antibody responses
av: Gorny MK, et al.
Publicerad: (2006-12-01)

Monoclonal antibodies to HIV-1 gp120: a request.
av: Moore, J, et al.
Publicerad: (1993)

Molecular mimicry of HIV gp120: Possible implications on prevention and therapy of AIDS
av: Veljković Nevena V.
Publicerad: (2005-01-01)

Hyperglycosylated resurfaced stabilized GP120 core as an immunogen elicits antibodies targeted at the CD4-binding site
av: Dai K, et al.
Publicerad: (2012-09-01)

Enhancement of soluble CD4-mediated HIV neutralization and gp 120 binding by CD4 autoantibodies and monoclonal antibodies.
av: Moore, J, et al.
Publicerad: (1990)

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.
av: Constantinos Kurt Wibmer, et al.
Publicerad: (2017-01-01)

Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
av: Moore, J, et al.
Publicerad: (1995)

Engineered gp120 immunogens that elicit VRC01-like antibodies by vaccination
av: Mata-Fink, Jordi, et al.
Publicerad: (2013)

Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.
av: Mondor, I, et al.
Publicerad: (1998)

Glycan microheterogeneity at the PGT135 antibody recognition site on HIV-1 gp120 reveals a molecular mechanism for neutralization resistance.
av: Pritchard, L, et al.
Publicerad: (2015)

Characterization of gp120 and Its Single-chain Derivatives, gp120-CD4 and gp120-M9: Implications for Targeting the CD4i Epitope in HIV-1 Vaccine Design
av: Shiver John
Publicerad: (2005-12-01)

A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies
av: Evan M. Cale, et al.
Publicerad: (2024-12-01)

Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
av: Jean-Philippe Julien, et al.
Publicerad: (2013-01-01)

Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
av: Nika M. Strokappe, et al.
Publicerad: (2019-06-01)

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7.
av: Sakaorat Lertjuthaporn, et al.
Publicerad: (2018-08-01)

Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.
av: Mei-Yun Zhang, et al.
Publicerad: (2012-01-01)

Engineering of HIV gp120 by yeast surface display for neutralizing antibody characterization and immunogen design
av: Mata-Fink, Jordi
Publicerad: (2013)

Kinetic Analysis of Monoclonal Antibody Binding to HIV-1 gp120-derived Hyperglycosylated Cores
av: Jidnyasa Ingale, et al.
Publicerad: (2015-10-01)

A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV infection and virus-mediated fusion.
av: Truneh, A, et al.
Publicerad: (1991)

Structural definition for a new modality of broad and potent antibody neutralization at the CD4-binding site on HIV-1 gp120
av: Zhou T, et al.
Publicerad: (2012-09-01)

Rapid development of cross-clade neutralizing antibody responses after clade B gp120/gp140 protein priming and clade c gp140 protein boosting
av: Spearman P, et al.
Publicerad: (2012-09-01)

Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.
av: Poignard, P, et al.
Publicerad: (1996)

A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.
av: Astronomo, R, et al.
Publicerad: (2008)

Functional epitope analysis of the human CD4 molecule. The MHC class II-dependent activation of resting T cells is inhibited by monoclonal antibodies to CD4 regardless whether or not they recognize epitopes involved in the binding of MHC class II or HIV gp120.
av: Merkenschlager, M, et al.
Publicerad: (1990)

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120
av: Matz J, et al.
Publicerad: (2012-09-01)

Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies.
av: Moore, J, et al.
Publicerad: (1994)

The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies
av: Dueñas-Decamp Maria J, et al.
Publicerad: (2012-01-01)

Structural basis for germline gene usage of a potent class of antibodies targeting the CD4 binding site of HIV-1 gp120
av: West AP, et al.
Publicerad: (2012-09-01)

Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
av: Simon, J, et al.
Publicerad: (1997)

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core
av: Andrew J Borst, et al.
Publicerad: (2018-11-01)

Cyanovirin-N binds to gp120 to interfere with CD4-dependent human immunodeficiency virus type 1 virion binding, fusion, and infectivity but does not affect the CD4 binding site on gp120 or soluble CD4-induced conformational changes in gp120.
av: Esser, M, et al.
Publicerad: (1999)

Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies.
av: Rachel C Doran, et al.
Publicerad: (2018-01-01)

Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop.
av: Yali Qin, et al.
Publicerad: (2015-01-01)

Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast
av: Mata-Fink, Jordi, et al.
Publicerad: (2015)

Reciprocal recognition of an HLA-Cw4-restricted HIV-1 gp120 epitope by CD8+ T cells and NK cells.
av: Thananchai, H, et al.
Publicerad: (2009)