Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults
Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of...
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| Fformat: | Journal article |
| Iaith: | English |
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Nature Research
2024
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| _version_ | 1826313742883749888 |
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| author | Pozarickij, A Gan, W Lin, K Clarke, R Fairhurst-Hunter, Z Koido, M Kanai, M Okada, Y Kamatani, Y Bennett, D Du, H Chen, Y Yang, L Avery, D Guo, Y Yu, M Yu, C Schmidt Valle, D Lv, J Chen, J Peto, R Collins, R Li, L Chen, Z Millwood, IY Walters, RG |
| author_facet | Pozarickij, A Gan, W Lin, K Clarke, R Fairhurst-Hunter, Z Koido, M Kanai, M Okada, Y Kamatani, Y Bennett, D Du, H Chen, Y Yang, L Avery, D Guo, Y Yu, M Yu, C Schmidt Valle, D Lv, J Chen, J Peto, R Collins, R Li, L Chen, Z Millwood, IY Walters, RG |
| author_sort | Pozarickij, A |
| collection | OXFORD |
| description | Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated that BP traits contribute differently to the causal associations of BP with CVD. In particular, only pulse pressure was independently causally associated with carotid plaque. These findings reinforce the need for studies in diverse populations to understand the genetic determinants of BP traits and their roles in disease risk. |
| first_indexed | 2024-09-25T04:21:21Z |
| format | Journal article |
| id | oxford-uuid:f79fa314-a1a1-42fb-a879-f4a95f065802 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:21:21Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:f79fa314-a1a1-42fb-a879-f4a95f0658022024-08-02T19:33:51ZCausal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f79fa314-a1a1-42fb-a879-f4a95f065802EnglishJisc Publications RouterNature Research2024Pozarickij, AGan, WLin, KClarke, RFairhurst-Hunter, ZKoido, MKanai, MOkada, YKamatani, YBennett, DDu, HChen, YYang, LAvery, DGuo, YYu, MYu, CSchmidt Valle, DLv, JChen, JPeto, RCollins, RLi, LChen, ZMillwood, IYWalters, RGElevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated that BP traits contribute differently to the causal associations of BP with CVD. In particular, only pulse pressure was independently causally associated with carotid plaque. These findings reinforce the need for studies in diverse populations to understand the genetic determinants of BP traits and their roles in disease risk. |
| spellingShingle | Pozarickij, A Gan, W Lin, K Clarke, R Fairhurst-Hunter, Z Koido, M Kanai, M Okada, Y Kamatani, Y Bennett, D Du, H Chen, Y Yang, L Avery, D Guo, Y Yu, M Yu, C Schmidt Valle, D Lv, J Chen, J Peto, R Collins, R Li, L Chen, Z Millwood, IY Walters, RG Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_full | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_fullStr | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_full_unstemmed | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_short | Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults |
| title_sort | causal relevance of different blood pressure traits on risk of cardiovascular diseases gwas and mendelian randomisation in 100 000 chinese adults |
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