HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities

HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities

Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E h...

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Main Authors: Yang, H, Rei, M, Brackenridge, S, Brenna, E, Sun, H, Abdulhaqq, S, Liu, MKP, Ma, W, Kurupati, P, Xu, X, Cerundolo, V, Jenkins, E, Davis, SJ, Sacha, JB, Früh, K, Picker, LJ, Borrow, P, Gillespie, GM, McMichael, AJ
格式: Journal article
语言:English
出版: American Association for the Advancement of Science 2021

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