Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.

<h4>Objectives</h4> <p>To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age.</p> <h4>Design</h4> <p>Analysis of genotype, PCa status, and age to select sin...

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Main Authors: Seibert, TM, Fan, CC, Wang, Y, Zuber, V, Karunamuni, R, Parsons, JK, Eeles, RA, Easton, DF, Kote-Jarai, Z, Olama, AA, Garcia, SB, Muir, K, Grönberg, H, Wiklund, F, Aly, M, Schleutker, J, Sipeky, C, Tammela, TL, Nordestgaard, BG, Nielsen, SF, Weischer, M, Bisbjerg, R, Røder, MA, Iversen, P, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, P, Pashayan, N, Khaw, K-T, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Brenner, H, Cuk, K, Saum, K-U, Park, JY, Sellers, TA, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Clements, JA, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Pandha, H, Michael, A, Kierzek, A, Karow, DS, Mills, IG, Andreassen, OA, Dale, AM
Format: Journal article
Language:English
Published: BMJ Publishing Group 2018

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