Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis.
The microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apoptotic signalling cascades, the glycolytic pathway and various cell-cycle control proteins. A...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1826305662710185984 |
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| author | Knowles, H Harris, A |
| author_facet | Knowles, H Harris, A |
| author_sort | Knowles, H |
| collection | OXFORD |
| description | The microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apoptotic signalling cascades, the glycolytic pathway and various cell-cycle control proteins. At the cellular level it mediates the infiltration and accumulation of tumour-associated macrophages within avascular tumour regions. Complex interactions between tumour cell and macrophage hypoxia-regulated gene products and their associated pathways form the basis for the hypoxic promotion of tumourigenesis and malignant progression. |
| first_indexed | 2024-03-07T06:36:15Z |
| format | Journal article |
| id | oxford-uuid:f7bcbd10-010d-4c0f-91c2-03ce1dc27bae |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:36:15Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:f7bcbd10-010d-4c0f-91c2-03ce1dc27bae2022-03-27T12:44:55ZHypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f7bcbd10-010d-4c0f-91c2-03ce1dc27baeEnglishSymplectic Elements at Oxford2001Knowles, HHarris, AThe microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apoptotic signalling cascades, the glycolytic pathway and various cell-cycle control proteins. At the cellular level it mediates the infiltration and accumulation of tumour-associated macrophages within avascular tumour regions. Complex interactions between tumour cell and macrophage hypoxia-regulated gene products and their associated pathways form the basis for the hypoxic promotion of tumourigenesis and malignant progression. |
| spellingShingle | Knowles, H Harris, A Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis. |
| title | Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis. |
| title_full | Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis. |
| title_fullStr | Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis. |
| title_full_unstemmed | Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis. |
| title_short | Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis. |
| title_sort | hypoxia and oxidative stress in breast cancer hypoxia and tumourigenesis |
| work_keys_str_mv | AT knowlesh hypoxiaandoxidativestressinbreastcancerhypoxiaandtumourigenesis AT harrisa hypoxiaandoxidativestressinbreastcancerhypoxiaandtumourigenesis |