Early life factors in the pathogenesis of osteoporosis.
Osteoporosis is a major public health burden through associated fragility fractures. Bone mass, a composite of bone size and volumetric density, increases through early life and childhood to a peak in early adulthood. The peak bone mass attained is a strong predictor of future risk of osteoporosis....
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797104623633301504 |
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| author | Winsloe, C Earl, S Dennison, E Cooper, C Harvey, N |
| author_facet | Winsloe, C Earl, S Dennison, E Cooper, C Harvey, N |
| author_sort | Winsloe, C |
| collection | OXFORD |
| description | Osteoporosis is a major public health burden through associated fragility fractures. Bone mass, a composite of bone size and volumetric density, increases through early life and childhood to a peak in early adulthood. The peak bone mass attained is a strong predictor of future risk of osteoporosis. Evidence is accruing that environmental factors in utero and in early infancy may permanently modify the postnatal pattern of skeletal growth to peak and thus influence risk of osteoporosis in later life. This article describes the latest data in this exciting area of research, including novel epigenetic and translation work, which should help to elucidate the underlying mechanisms and give rise to potential public health interventions to reduce the burden of osteoporotic fracture in future generations. |
| first_indexed | 2024-03-07T06:36:20Z |
| format | Journal article |
| id | oxford-uuid:f7c82dbf-2c75-4e7a-8d61-879ac33901ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:36:20Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:f7c82dbf-2c75-4e7a-8d61-879ac33901ad2022-03-27T12:45:05ZEarly life factors in the pathogenesis of osteoporosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f7c82dbf-2c75-4e7a-8d61-879ac33901adEnglishSymplectic Elements at Oxford2009Winsloe, CEarl, SDennison, ECooper, CHarvey, NOsteoporosis is a major public health burden through associated fragility fractures. Bone mass, a composite of bone size and volumetric density, increases through early life and childhood to a peak in early adulthood. The peak bone mass attained is a strong predictor of future risk of osteoporosis. Evidence is accruing that environmental factors in utero and in early infancy may permanently modify the postnatal pattern of skeletal growth to peak and thus influence risk of osteoporosis in later life. This article describes the latest data in this exciting area of research, including novel epigenetic and translation work, which should help to elucidate the underlying mechanisms and give rise to potential public health interventions to reduce the burden of osteoporotic fracture in future generations. |
| spellingShingle | Winsloe, C Earl, S Dennison, E Cooper, C Harvey, N Early life factors in the pathogenesis of osteoporosis. |
| title | Early life factors in the pathogenesis of osteoporosis. |
| title_full | Early life factors in the pathogenesis of osteoporosis. |
| title_fullStr | Early life factors in the pathogenesis of osteoporosis. |
| title_full_unstemmed | Early life factors in the pathogenesis of osteoporosis. |
| title_short | Early life factors in the pathogenesis of osteoporosis. |
| title_sort | early life factors in the pathogenesis of osteoporosis |
| work_keys_str_mv | AT winsloec earlylifefactorsinthepathogenesisofosteoporosis AT earls earlylifefactorsinthepathogenesisofosteoporosis AT dennisone earlylifefactorsinthepathogenesisofosteoporosis AT cooperc earlylifefactorsinthepathogenesisofosteoporosis AT harveyn earlylifefactorsinthepathogenesisofosteoporosis |