Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

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AIMS: The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de-Pointes (TdP) arrhythmias. While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold...

Полное описание

Библиографические подробности
Главные авторы:	Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D
Формат:	Journal article
Язык:	English
Опубликовано:	2011

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