Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Εμφάνιση άλλων εκδόσεων (1)

AIMS: The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de-Pointes (TdP) arrhythmias. While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2011

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