Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Mostra altre versioni (1)

AIMS: The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de-Pointes (TdP) arrhythmias. While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D
Natura:	Journal article
Lingua:	English
Pubblicazione:	2011

Documenti analoghi

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk
di: Mirams, G, et al.
Pubblicazione: (2011)

THE L-TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES
di: Sher, A, et al.
Pubblicazione: (2009)

L−TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES
di: Sher, A, et al.
Pubblicazione: (2009)

Torsadogenic index for prevention of acute death
di: Adrián Ángel Inchauspe
Pubblicazione: (2015-10-01)

Four ways to fit an ion channel model
di: Clerx, M, et al.
Pubblicazione: (2019)

Role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in the anesthetized atrioventricular block rabbit
di: Satoshi Kawakami, et al.
Pubblicazione: (2022-10-01)

Hierarchical Bayesian inference for ion channel screening dose-response data
di: Johnstone, R, et al.
Pubblicazione: (2016)

Torsadogenic drug−induced increased short−term variability of JT−area
di: Jie, X, et al.
Pubblicazione: (2010)

In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model
di: Mihoko Hagiwara, et al.
Pubblicazione: (2016-09-01)

Rapid changes of mRNA expressions of cardiac ion channels affected by Torsadogenic drugs influence susceptibility of rat hearts to arrhythmias induced by Beta‐Adrenergic stimulation
di: Katarina Hadova, et al.
Pubblicazione: (2023-10-01)

Variability in high−throughput ion channel screening data and consequences for cardiac safety assessment
di: Elkins, R, et al.
Pubblicazione: (2013)

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
di: Elkins, R, et al.
Pubblicazione: (2013)

A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling
di: Sher, A, et al.
Pubblicazione: (2013)

A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to Cardiac Ionic Channel Modelling
di: Sher, A, et al.
Pubblicazione: (2013)

A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling
di: Sher, A, et al.
Pubblicazione: (2013)

Markov models for ion channels: versatility versus identifiability and speed.
di: Fink, M, et al.
Pubblicazione: (2009)

Torsadogenic potential of a novel remyelinating drug clemastine for multiple sclerosis assessed in the rabbit proarrhythmia model
di: Satoshi Kawakami, et al.
Pubblicazione: (2020-11-01)

TORSADOGENIC INDEX: A proposal to improve survival rates in cardiac arrests due to prescribed drugs
di: Adrián Angel Angel Inchauspe
Pubblicazione: (2012-06-01)

Torsadogenic risk of antipsychotics: combining adverse event reports with drug utilization data across Europe.
di: Emanuel Raschi, et al.
Pubblicazione: (2013-01-01)

Prediction of Thorough QT study results using action potential simulations based on ion channel screens
di: Mirams, G, et al.
Pubblicazione: (2014)

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics
di: Beattie, KA, et al.
Pubblicazione: (2018)

A Local Sensitivity Analysis Method for Developing Biological Models with Identifiable Parameters: Application to L−type Calcium Channel Modelling
di: Sher, A, et al.
Pubblicazione: (2010)

Computational assessment of drug−induced effects on the electrocardiogram: from ion channel block to body surface potentials
di: Zemzemi, N, et al.
Pubblicazione: (2013)

A comparison of existing and new methods for Torsade de Pointes risk classification based on multi-ion channel screening
di: McMillan, B, et al.
Pubblicazione: (2017)

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge
di: Beattie, K, et al.
Pubblicazione: (2013)

Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge
di: Beattie, K, et al.
Pubblicazione: (2013)

Pharmacological β-adrenoceptor blockade can augment torsadogenic action of IKr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs
di: Ai Goto, et al.
Pubblicazione: (2019-09-01)

Hierarchical Bayesian inference for ion channel screening dose-response data [version 2; referees: 2 approved]
di: Ross H Johnstone, et al.
Pubblicazione: (2017-03-01)

Evaluation of computational modelling as a preclinical proarrhythmic safety assay
di: Mirams, G, et al.
Pubblicazione: (2013)

Grid Computing Simulations of Ion Channel Block Effects on the ECG Using 3D Anatomically−Based Models
di: Gavaghan D Bernabeu MO Corrias A Pitt−Francis J Rodriguez B Bethwaite B Enticott C Garic S Peachey T Tan J Abramson D
Pubblicazione: (2009)

Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects
di: Ai Goto, et al.
Pubblicazione: (2018-06-01)

Neural Network Differential Equations For Ion Channel Modelling
di: Chon Lok Lei, et al.
Pubblicazione: (2021-08-01)

Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system
di: Lei, CL, et al.
Pubblicazione: (2019)

Modulating ion channels with nanobodies
di: Sher Ali, et al.
Pubblicazione: (2025-06-01)

The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels
di: Katsumasa Irie
Pubblicazione: (2021-12-01)

Long alkylchain iminosugars block the HCV p7 ion channel
di: Pavlovic, D, et al.
Pubblicazione: (2005)

Ion channels: Growing evidence for the role in disease
di: Han, J, et al.
Pubblicazione: (2010)

The role of the Na+/Ca2+ exchangers in Ca2+ dynamics in ventricular myocytes.
di: Sher, A, et al.
Pubblicazione: (2008)

Functional significance of Na+/Ca2+ exchangers co-localization with ryanodine receptors.
di: Sher, A, et al.
Pubblicazione: (2007)

role of the Na+/Ca2+ exchangers in Ca2+ dynamics in ventricular myocytes
di: Sher, A, et al.
Pubblicazione: (2015)