Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

AIMS: The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a compound causing Torsade-de-Pointes (TdP) arrhythmias. While avoiding the use of drugs with maximum therapeutic concentrations within 30-fold...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D
Formato:	Journal article
Lenguaje:	English
Publicado:	2011

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk por Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D

Publicado 2011

Journal article

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk por Mirams, G, Cui, Y, Sher, A, Fink, M, Cooper, J, Heath, B, McMahon, N, Gavaghan, D, Noble, D

Ejemplares similares