Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.

Refsum disease (RD), a neurological syndrome characterized by adult onset retinitis pigmentosa, anosmia, sensory neuropathy, and phytanic acidaemia, is caused by elevated levels of phytanic acid. Many cases of RD are associated with mutations in phytanoyl-CoA 2-hydroxylase (PAHX), an Fe(II) and 2-ox...

Полное описание

Библиографические подробности
Главные авторы: McDonough, M, Kavanagh, K, Butler, D, Searls, T, Oppermann, U, Schofield, C
Формат: Journal article
Язык:English
Опубликовано: 2005