Using a human challenge model of infection to measure vaccine efficacy: a randomised, controlled trial comparing the typhoid vaccines M01ZH09 with placebo and Ty21a

Using a human challenge model of infection to measure vaccine efficacy: a randomised, controlled trial comparing the typhoid vaccines M01ZH09 with placebo and Ty21a

BACKGROUND: Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious vaccines is complicated by the human h...

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Main Authors: Darton, T, Jones, C, Blohmke, C, Waddington, C, Zhou, L, Peters, A, Haworth, K, Sie, R, Green, C, Jeppesen, C, Moore, M, Thompson, B, John, T, Kingsley, R, Yu, L, Voysey, M, Hindle, Z, Lockhart, S, Sztein, M, Dougan, G, Angus, B, Levine, M, Pollard, A
格式: Journal article
语言:English
出版: Public Library of Science 2016

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