Discovering markers of healthy aging: a prospective study in a Danish male birth cohort
There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Part...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Impact Journals
2019
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| _version_ | 1797104667236237312 |
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| author | Zarnani, K Nichols, TE Alfaro-Almagro, F Fagerlund, B Lauritzen, M Rostrup, E Smith, SM |
| author_facet | Zarnani, K Nichols, TE Alfaro-Almagro, F Fagerlund, B Lauritzen, M Rostrup, E Smith, SM |
| author_sort | Zarnani, K |
| collection | OXFORD |
| description | There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recruited from the 1953 Danish Male Birth Cohort (N=193). Applying an extreme group design, members were selected in 2 groups based on cognitive change between IQ at age ~20y (IQ-20) and age ~57y (IQ-57). Subjects showing the highest (n=95) and lowest (n=98) change were selected (at age ~57) for assessments on multiple IDPs and non-IDPs. We investigated the relationship between 453 IDPs and 70 non-IDPs through pairwise correlation and multivariate canonical correlation analysis (CCA) models. Significant pairwise associations included positive associations between IQ-20 and gray-matter volume of the temporal pole. CCA identified a richer pattern - a single "positive-negative" mode of population co-variation coupling individual cross-subject variations in IDPs to an extensive range of non-IDP measures (r = 0.75, Pcorrected < 0.01). Specifically, this mode linked higher cognitive performance, positive early-life social factors, and mental health to a larger brain volume of several brain structures, overall volume, and microstructural properties of some white matter tracts. Interestingly, both statistical models identified IQ-20 and gray-matter volume of the temporal pole as important contributors to the inter-individual variation observed. The converging patterns provide novel insight into the importance of early adulthood intelligence as a significant marker of late-midlife neural decline and motivates additional study. |
| first_indexed | 2024-03-07T06:36:50Z |
| format | Journal article |
| id | oxford-uuid:f7f1a2fe-09a6-4c5e-b99e-069174429615 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:36:50Z |
| publishDate | 2019 |
| publisher | Impact Journals |
| record_format | dspace |
| spelling | oxford-uuid:f7f1a2fe-09a6-4c5e-b99e-0691744296152022-03-27T12:46:32ZDiscovering markers of healthy aging: a prospective study in a Danish male birth cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f7f1a2fe-09a6-4c5e-b99e-069174429615EnglishSymplectic Elements at OxfordImpact Journals2019Zarnani, KNichols, TEAlfaro-Almagro, FFagerlund, BLauritzen, MRostrup, ESmith, SMThere is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recruited from the 1953 Danish Male Birth Cohort (N=193). Applying an extreme group design, members were selected in 2 groups based on cognitive change between IQ at age ~20y (IQ-20) and age ~57y (IQ-57). Subjects showing the highest (n=95) and lowest (n=98) change were selected (at age ~57) for assessments on multiple IDPs and non-IDPs. We investigated the relationship between 453 IDPs and 70 non-IDPs through pairwise correlation and multivariate canonical correlation analysis (CCA) models. Significant pairwise associations included positive associations between IQ-20 and gray-matter volume of the temporal pole. CCA identified a richer pattern - a single "positive-negative" mode of population co-variation coupling individual cross-subject variations in IDPs to an extensive range of non-IDP measures (r = 0.75, Pcorrected < 0.01). Specifically, this mode linked higher cognitive performance, positive early-life social factors, and mental health to a larger brain volume of several brain structures, overall volume, and microstructural properties of some white matter tracts. Interestingly, both statistical models identified IQ-20 and gray-matter volume of the temporal pole as important contributors to the inter-individual variation observed. The converging patterns provide novel insight into the importance of early adulthood intelligence as a significant marker of late-midlife neural decline and motivates additional study. |
| spellingShingle | Zarnani, K Nichols, TE Alfaro-Almagro, F Fagerlund, B Lauritzen, M Rostrup, E Smith, SM Discovering markers of healthy aging: a prospective study in a Danish male birth cohort |
| title | Discovering markers of healthy aging: a prospective study in a Danish male birth cohort |
| title_full | Discovering markers of healthy aging: a prospective study in a Danish male birth cohort |
| title_fullStr | Discovering markers of healthy aging: a prospective study in a Danish male birth cohort |
| title_full_unstemmed | Discovering markers of healthy aging: a prospective study in a Danish male birth cohort |
| title_short | Discovering markers of healthy aging: a prospective study in a Danish male birth cohort |
| title_sort | discovering markers of healthy aging a prospective study in a danish male birth cohort |
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