Resistance to malaria through structural variation of red blood cell invasion receptors

Resistance to malaria through structural variation of red blood cell invasion receptors

Plasmodium falciparum invades erythrocytes via interactions with proteins on the host cell surface. By analyzing genome sequence data from human populations, including 1269 African individuals, we identify a diverse array of large copy number variants affecting the erythrocyte invasion receptor gene...

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Main Authors: Leffler, E, Band, G, Clarke, G, Kivinen, K, Le, Q, Bojang, K, Conway, D, Jallow, M, Sisay-Joof, F, Bougouma, E, Mangano, V, Modiano, D, Sirima, S, Achidi, E, Apinjoh, T, Marsh, K, Ndila, C, Peshu, N, Williams, T, Drakeley, C, Manjurano, A, Reyburn, H, Riley, E, Kachala, D, Molyneux, M, Nyirongo, V, Taylor, T, Thornton, N, Tilley, L, Grimsley, S, Drury, E, Stalker, J, Cornelius, V, Hubbart, C, Jeffreys, A, Rowlands, K, Rockett, K, Spencer, C, Kwiatkowski, D, Malaria Genomic Epidemiology Network
格式: Journal article
出版: American Association for the Advancement of Science 2017

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